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Substance Name: Acetoxycycloheximide
RN: 2885-39-4
UNII: UX3Y1I395S
InChIKey: UFDHNJJHPSGMFX-SQUSCZTCSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C17-H25-N-O6

Molecular Weight

  • 339.385
 
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Names and Synonyms

Name of Substance

  • Acetoxycycloheximide

Synonyms

  • 3-(2-(5-Acetoxy-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide
  • 4-Acetoxycycloheximide
  • Acetoxycycloheximide
  • Acetyloxycycloheximide
  • Antibiotic from Streptomyces albulus
  • AXM
  • Cycloheximide, 4-acetoxy-
  • E 73
  • E-73 acetate
  • Glutarimide, 3-(2-(5-acetoxy-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-
  • NSC 32743
  • Streptovitacin E 73
  • UNII-UX3Y1I395S

Systematic Names

  • 2,6-Piperidinedione, 4-(2-(5-(acetyloxy)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5alpha))- (9CI)
  • 3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide acetate
  • Glutarimide, 3-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl)-, 5-acetate
  • Glutarimide, 3-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl)-,5-acetate (8CI)

Registry Numbers

CAS Registry Number

  • 2885-39-4

FDA UNII

  • UX3Y1I395S

Other Registry Numbers

  • 11037-68-6
  • 14172-67-9
  • 3326-96-3

System Generated Number

  • 0002885394

Structure Descriptors

InChI

1S/C17H25NO6/c1-9-7-17(3,24-10(2)19)8-12(16(9)23)13(20)4-11-5-14(21)18-15(22)6-11/h9,11-13,20H,4-8H2,1-3H3,(H,18,21,22)/t9-,12-,13+,17+/m0/s1

InChIKey

UFDHNJJHPSGMFX-SQUSCZTCSA-N

Smiles

C1([C@H]([C@@H](CC2CC(NC(C2)=O)=O)O)C[C@@](OC(=O)C)(C)C[C@@H]1C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 920ug/kg (0.92mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: COMA
Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 400, 1962.
mouse LD50 intraperitoneal 19mg/kg (19mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 400, 1962.
rat LD50 intraperitoneal 170ug/kg (0.17mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 400, 1962.
rat LD50 oral 158ug/kg (0.158mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 400, 1962.
rat LD50 subcutaneous 190ug/kg (0.19mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 400, 1962.