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Substance Name: Delorazepam [INN]
RN: 2894-67-9
UNII: O91W32476G
InChIKey: CHIFCDOIPRCHCF-UHFFFAOYSA-N

Molecular Formula

  • C15-H10-Cl2-N2-O

Molecular Weight

  • 305.163
 

Classification Codes

Classification Codes

  • Anticonvulsants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Chlordesmethyldiazepam
  • Delorazepam [INN]

Synonyms

  • 1,3-Dihydro-7-chloro-5-(o-chlorophenyl)-2H-1,4-benzodiazepin-2-one
  • 2-Chloronordiazepam
  • 5-24-04-00331 (Beilstein Handbook Reference)
  • B1, Benzodiazepine
  • BRN 0754062
  • Chlordemethyldiazepam
  • Chlordesmethyldiazepam
  • Cl-DMDZ
  • Clordesmetildiazepam
  • Clordesmetildiazepam [Spanish]
  • Delorazepam
  • Delorazepamum
  • Delorazepamum [INN-Latin]
  • EINECS 220-771-9
  • EN [Anticonvulsant]
  • NSC 169895
  • Ro 5-3027
  • RV-12165
  • UNII-O91W32476G

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-chlorophenyl)-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro- (9CI)
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro- (8CI)
  • 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Delorazepam

Superlist Names

  • DEA No. 2754
  • Delorazepam

Registry Numbers

CAS Registry Number

  • 2894-67-9

FDA UNII

  • O91W32476G

System Generated Number

  • 0002894679

Structure Descriptors

InChI

1S/C15H10Cl2N2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

InChIKey

CHIFCDOIPRCHCF-UHFFFAOYSA-N

Smiles

c12C(=NCC(=O)Nc1ccc(c2)Cl)c1c(cccc1)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 28ug/kg (0.028mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ANTIANXIETY
Journal of Clinical Pharmacology. Vol. 16, Pg. 481, 1976.
mouse LD50 intraperitoneal 49390ug/kg (49.39mg/kg)   Bollettino Chimico Farmaceutico. Vol. 125, Pg. 31, 1986.
mouse LD50 intravenous 69890ug/kg (69.89mg/kg)   Bollettino Chimico Farmaceutico. Vol. 125, Pg. 31, 1986.
mouse LD50 oral 940mg/kg (940mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 154, Pg. 131, 1965.
rabbit LD50 intravenous 25050ug/kg (25.05mg/kg)   Bollettino Chimico Farmaceutico. Vol. 125, Pg. 31, 1986.
rat LD50 intraperitoneal 46780ug/kg (46.78mg/kg)   Bollettino Chimico Farmaceutico. Vol. 125, Pg. 31, 1986.
rat LD50 intravenous 55860ug/kg (55.86mg/kg)   Bollettino Chimico Farmaceutico. Vol. 125, Pg. 31, 1986.
rat LD50 oral 2gm/kg (2000mg/kg)   Medicamentos de Actualidad. Vol. 15, Pg. 173, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.15 (none)   EXP
Water Solubility 23.4 mg/L 25 EST
Vapor Pressure 1.74E-09 mm Hg 25 EST
Henry's Law Constant 1.32E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.70E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.