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Substance Name: Medazepam hydrochloride [USAN]
RN: 2898-11-5
UNII: ETM878JC9K
InChIKey: XBWAZCLHZCFCGK-UHFFFAOYSA-N

Note

  • A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM.

Molecular Formula

  • C16-H15-Cl-N2.Cl-H

Molecular Weight

  • 307.2224
 

Classification Codes

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Drug / Therapeutic Agent
  • GABA Modulators
  • Hypnotics and Sedatives
  • Muscle Relaxants, Central
  • Reproductive Effect
  • Tranquilizer (Minor)
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Names and Synonyms

Name of Substance

  • Medazepam hydrochloride
  • Medazepam hydrochloride [USAN]

Synonyms

  • 7-Chlor-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin hydrochlorid
  • 7-Chlor-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin hydrochlorid [German]
  • 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine monohydrochloride
  • 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine, hydrochloride
  • CCRIS 1916
  • Diepin
  • EINECS 220-782-9
  • Elbrus
  • Esmail
  • Medazepam HCl
  • Medazepam hydrochloride
  • Medazepol
  • Megasedan
  • Mezepan
  • Nobrium
  • NSC 169896
  • Ro 5-4556
  • UNII-ETM878JC9K

Systematic Names

  • 1H-1,4-Benzodiazepine, 7-chloro-2,3-dihydro-1-methyl-5-phenyl, monohydrochloride
  • 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-benzo-1,4-diazepine monohydrochloride
  • Medazepam hydrochloride

Registry Numbers

CAS Registry Number

  • 2898-11-5

FDA UNII

  • ETM878JC9K

Related Registry Number

  • 2898-12-6 (Parent)

System Generated Number

  • 0002898115

Molecular Formulas

Molecular Formula

  • C16-H15-Cl-N2.Cl-H

Molecular Formula Fragments

  • C16-H15-Cl-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H15ClN2.ClH/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19;/h2-8,11H,9-10H2,1H3;1H

InChIKey

XBWAZCLHZCFCGK-UHFFFAOYSA-N

Smiles

CN1CCN=C(c2c1ccc(c2)Cl)c3ccccc3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 314mg/kg (314mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 833, 1970.
mouse LD50 intravenous 47mg/kg (47mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 833, 1970.
mouse LD50 oral 710mg/kg (710mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 1542, 1968.
mouse LD50 subcutaneous 720mg/kg (720mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 1542, 1968.
rabbit LD50 oral 530mg/kg (530mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 1542, 1968.
rat LD50 intraperitoneal 210mg/kg (210mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 1542, 1968.
rat LD50 intravenous 91mg/kg (91mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 833, 1970.
rat LD50 oral 900mg/kg (900mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 1700mg/kg (1700mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 1542, 1968.