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Substance Name: Medazepam [INN:BAN:JAN]
RN: 2898-12-6
UNII: P0J3387W3S
InChIKey: YLCXGBZIZBEVPZ-UHFFFAOYSA-N

Note

  • A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM.

Molecular Formula

  • C16-H15-Cl-N2

Molecular Weight

  • 270.7615
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Hypnotics and Sedatives
  • Muscle Relaxants, Central
  • Mutation Data
  • Neuromuscular Agents
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Results Name

  • Medazepam [INN:BAN:JAN]

Name of Substance

  • Medazepam
  • Medazepam [INN:BAN:JAN]

MeSH Heading

  • Medazepam

Synonyms

  • 1H-1,4-Benzodiazepine, 2,3-dihydro-7-chloro-1-methyl-5-phenyl-
  • 2,3-Dihydro-7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine
  • 5-23-09-00037 (Beilstein Handbook Reference)
  • 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine
  • 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-3H-1,4-benzodiazepine
  • Aensius
  • Ansilan
  • Azepamide
  • Benaon
  • BRN 0407983
  • EINECS 220-783-4
  • Enobrin
  • Lerisum
  • Medaurin
  • Medazepam
  • Medazepamum
  • Medazepamum [INN-Latin]
  • Narsis
  • Navizil
  • Nivelton
  • Nobraksin
  • Nobral
  • Nobrium
  • RB 252
  • Resmit
  • Rudotel
  • S 804
  • Stratium
  • UNII-P0J3387W3S

Systematic Names

  • 1H-1,4-Benzodiazepine, 7-chloro-2,3-dihydro-1-methyl-5-phenyl-
  • Medazepam

Superlist Names

  • DEA No. 2836
  • Medazepam

Registry Numbers

CAS Registry Number

  • 2898-12-6

FDA UNII

  • P0J3387W3S

Related Registry Number

  • 2898-11-5 (mono-hydrochloride)

System Generated Number

  • 0002898126

Structure Descriptors

InChI

1S/C16H15ClN2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19/h2-8,11H,9-10H2,1H3

InChIKey

YLCXGBZIZBEVPZ-UHFFFAOYSA-N

Smiles

C1(=NCCN(c2c1cc(cc2)Cl)C)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 750mg/kg (750mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 11, Pg. 1109, 1969.
mouse LD50 intraperitoneal 360mg/kg (360mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 185, Pg. 135, 1970.
mouse LD50 intravenous 44mg/kg (44mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 463, 1971.
mouse LD50 oral 475mg/kg (475mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 2029, 1974.
mouse LD50 subcutaneous 6750mg/kg (6750mg/kg)   Drugs in Japan Vol. -, Pg. 1164, 1990.
rat LD50 intraperitoneal 239mg/kg (239mg/kg)   Drugs in Japan Vol. -, Pg. 1164, 1990.
rat LD50 intravenous 92mg/kg (92mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 461, 1971.
rat LD50 oral 900mg/kg (900mg/kg)   "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973Vol. -, Pg. 35, 1973.
rat LD50 subcutaneous 2980mg/kg (2980mg/kg)   Drugs in Japan Vol. -, Pg. 1164, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.41 (none)   EXP
Water Solubility 3.100 mg/L 25 EST
Vapor Pressure 2.13E-06 mm Hg 25 EST
Henry's Law Constant 1.64E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.87E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.