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Substance Name: Seclazone [USAN:INN]
RN: 29050-11-1
UNII: JW3UZ4I1A8
InChIKey: XWXVKXXKKLBDDJ-UHFFFAOYSA-N

Classification Codes

  • Anti-Inflammatory
  • Drug / Therapeutic Agent
  • Uricosuric
  • Uricosuric Agents

Molecular Formula

  • C10-H8-Cl-N-O3

Molecular Weight

  • 225.6302
 
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Names and Synonyms

Name of Substance

  • Seclazone
  • Seclazone [USAN:INN]

Synonyms

  • 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 7-chloro-3,3a-dihydro-
  • 3,3a-Dihydro-7-chloro-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one
  • 7-Chloro-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one
  • BRN 1078684
  • NSC 294833
  • Seclazona
  • Seclazona [INN-Spanish]
  • Seclazone
  • Seclazonum
  • Seclazonum [INN-Latin]
  • UNII-JW3UZ4I1A8
  • W 2352
  • W 2354
  • W-2354

Systematic Names

  • 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 3,3a-dihydro-7-chloro-
  • 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 7-chloro-3,3a-dihydro-
  • 7-Chloro-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one

Registry Numbers

CAS Registry Number

  • 29050-11-1

FDA UNII

  • JW3UZ4I1A8

System Generated Number

  • 0029050111

Structure Descriptors

InChI

1S/C10H8ClNO3/c11-6-1-2-8-7(5-6)10(13)12-9(15-8)3-4-14-12/h1-2,5,9H,3-4H2

InChIKey

XWXVKXXKKLBDDJ-UHFFFAOYSA-N

Smiles

Clc1ccc2OC3CCON3C(=O)c2c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 200mg/kg (200mg/kg) BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.
monkey LD50 oral > 400mg/kg (400mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.
mouse LD50 intraperitoneal 400mg/kg (400mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.
mouse LD50 oral 475mg/kg (475mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.
rat LD50 intraperitoneal 375mg/kg (375mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.
rat LD50 oral 1550mg/kg (1550mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.