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Substance Name: Seclazone [USAN:INN]
RN: 29050-11-1
UNII: JW3UZ4I1A8
InChIKey: XWXVKXXKKLBDDJ-UHFFFAOYSA-N
Classification Codes
- Anti-Inflammatory
- Drug / Therapeutic Agent
- Uricosuric
- Uricosuric Agents
Molecular Formula
- C10-H8-Cl-N-O3
Molecular Weight
- 225.6302
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Names and Synonyms
Name of Substance
- Seclazone
- Seclazone [USAN:INN]
Synonyms
- 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 7-chloro-3,3a-dihydro-
- 3,3a-Dihydro-7-chloro-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one
- 7-Chloro-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one
- BRN 1078684
- NSC 294833
- Seclazona
- Seclazona [INN-Spanish]
- Seclazone
- Seclazonum
- Seclazonum [INN-Latin]
- UNII-JW3UZ4I1A8
- W 2352
- W 2354
- W-2354
Systematic Names
- 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 3,3a-dihydro-7-chloro-
- 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 7-chloro-3,3a-dihydro-
- 7-Chloro-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one
Registry Numbers
CAS Registry Number
- 29050-11-1
FDA UNII
- JW3UZ4I1A8
System Generated Number
- 0029050111
Structure Descriptors
InChI
1S/C10H8ClNO3/c11-6-1-2-8-7(5-6)10(13)12-9(15-8)3-4-14-12/h1-2,5,9H,3-4H2InChIKey
XWXVKXXKKLBDDJ-UHFFFAOYSA-NSmiles
Clc1ccc2OC3CCON3C(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: FLUID INTAKE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973. |
| monkey | LD50 | oral | > 400mg/kg (400mg/kg) | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973. | |
| mouse | LD50 | intraperitoneal | 400mg/kg (400mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973. |
| mouse | LD50 | oral | 475mg/kg (475mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973. |
| rat | LD50 | intraperitoneal | 375mg/kg (375mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973. |
| rat | LD50 | oral | 1550mg/kg (1550mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973. |