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Substance Name: Terofenamate [INN]
RN: 29098-15-5
UNII: A53154FC4N
InChIKey: FRQSLQPWXFAJFO-UHFFFAOYSA-N

Note

  • Ethoxymethyl ester of meclofenamic acid; non-steroidal topical anti-inflammatory agent.

Molecular Formula

  • C17-H17-Cl2-N-O3

Molecular Weight

  • 354.2313
 

Classification Codes

  • Adrenal Cortex Hormones
  • Drug / Therapeutic Agent
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

Name of Substance

  • Terofenamate
  • Terofenamate [INN]

Synonyms

  • 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid ethoxymethyl ester
  • BRN 2894433
  • EINECS 249-434-4
  • Estere etossimetilico dell' acido N-(2,6-dicloro-m-tolil)antranilico
  • Estere etossimetilico dell' acido N-(2,6-dicloro-m-tolil)antranilico [Italian]
  • Ethoxymethyl N-(2,6-dichloro-m-tolyl)anthranilate
  • Etoclofene
  • Etofen
  • N-(2,6-Dichloro-m-tolyl)anthranilic acid ethoxymethyl ester
  • Terofenamate
  • Terofenamato
  • Terofenamato [INN-Spanish]
  • Terofenamatum
  • Terofenamatum [INN-Latin]
  • UNII-A53154FC4N

Systematic Names

  • Anthranilic acid, N-(2,6-dichloro-m-tolyl)-, ethoxymethyl ester
  • Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, ethoxymethyl ester (9CI)
  • Ethoxymethyl N-(2,6-dichloro-m-tolyl)anthranilate
  • M-(2,6-Dichloro-m-tolyl)anthranilic acid ethoxymethyl ester
  • Terofenamate

Registry Numbers

CAS Registry Number

  • 29098-15-5

FDA UNII

  • A53154FC4N

System Generated Number

  • 0029098155

Structure Descriptors

InChI

1S/C17H17Cl2NO3/c1-3-22-10-23-17(21)12-6-4-5-7-14(12)20-16-13(18)9-8-11(2)15(16)19/h4-9,20H,3,10H2,1-2H3

InChIKey

FRQSLQPWXFAJFO-UHFFFAOYSA-N

Smiles

CCOCOC(=O)c1ccccc1Nc2c(ccc(c2Cl)C)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 300mg/kg (300mg/kg) GASTROINTESTINAL: OTHER CHANGES Bollettino Chimico Farmaceutico. Vol. 115, Pg. 41, 1976.
mouse LD50 oral 918mg/kg (918mg/kg) GASTROINTESTINAL: OTHER CHANGES Bollettino Chimico Farmaceutico. Vol. 115, Pg. 41, 1976.
rat LD50 intraperitoneal 274mg/kg (274mg/kg) LUNGS, THORAX, OR RESPIRATION: COUGH Bollettino Chimico Farmaceutico. Vol. 115, Pg. 41, 1976.
rat LD50 oral 307mg/kg (307mg/kg) LUNGS, THORAX, OR RESPIRATION: COUGH Bollettino Chimico Farmaceutico. Vol. 115, Pg. 41, 1976.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 73.5 deg C   EXP
log P (octanol-water) 6.040 (none)   EST
Atmospheric OH Rate Constant 9.54E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.