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Substance Name: Guanfacine hydrochloride [USAN:USP:JAN]
RN: 29110-48-3
UNII: PML56A160O
InChIKey: DGFYECXYGUIODH-UHFFFAOYSA-N

Note

  • A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.

Molecular Formula

  • C9-H9-Cl2-N3-O.Cl-H

Molecular Weight

  • 282.557
 

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Guanfacine hydrochloride [USAN:USP:JAN]

Synonyms

  • BS 100-141
  • EINECS 249-443-3
  • Estulic
  • Guanfacine HCl
  • Guanfacine hydrochloride
  • Intuniv
  • LON 798
  • N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride
  • N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride
  • N-Amidino-2-(2,6-dichlorophenyl)acetamide monohydrochloride
  • SPD 503
  • SPD503
  • Tenex
  • UNII-PML56A160O

Systematic Names

  • Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, monohydrochloride
  • N-(Aminoiminomethyl)-2,6-dichlorophenylacetamide monohydrochloride

Registry Numbers

CAS Registry Number

  • 29110-48-3

FDA UNII

  • PML56A160O

Related Registry Number

  • 29110-47-2 (Parent)

System Generated Number

  • 0029110483

Molecular Formulas

Molecular Formula

  • C9-H9-Cl2-N3-O.Cl-H

Molecular Formula Fragments

  • C9-H9-Cl2-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

InChIKey

DGFYECXYGUIODH-UHFFFAOYSA-N

Smiles

c1cc(c(c(c1)Cl)CC(=O)NC(=N)N)Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.
mouse LD50 oral 15300ug/kg (15.3mg/kg)   Drugs in Japan Vol. -, Pg. 372, 1995.
mouse LD50 subcutaneous 46mg/kg (46mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.
rat LD50 intravenous 5800ug/kg (5.8mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.
rat LD50 oral 142mg/kg (142mg/kg)   Drugs in Japan Vol. -, Pg. 372, 1995.
rat LD50 subcutaneous 114mg/kg (114mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.