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Substance Name: Atenolol [USAN:USP:INN:BAN:JAN]
RN: 29122-68-7
UNII: 50VV3VW0TI
InChIKey: METKIMKYRPQLGS-UHFFFAOYSA-N

Note

  • A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.

Molecular Formula

  • C14-H22-N2-O3

Molecular Weight

  • 266.3388
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-1 Receptor Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Adrenergic (beta-Receptor)
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sympatholytics

Names and Synonyms

Name of Substance

  • Atenolol
  • Atenolol [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Atenolol

Synonyms

  • (RS)-Atenolol
  • 1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-propanol
  • 2-(4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl)acetamid
  • 2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
  • 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetamide
  • Aircrit
  • Alinor
  • Altol
  • Anselol
  • Antipressan
  • Apo-Atenolol
  • Atcard
  • Atcardil
  • Atecard
  • Atehexal
  • Atenblock
  • Atendol
  • Atenet
  • Ateni
  • Atenil
  • Atenol 1A pharma
  • Atenol acis
  • Atenol AL
  • Atenol Atid
  • Atenol Cophar
  • Atenol ct
  • Atenol Fecofar
  • Atenol Gador
  • Atenol Genericon
  • Atenol GNR
  • Atenol Heumann
  • Atenol MSD
  • Atenol NM Pharma
  • Atenol Nordic
  • Atenol PB
  • Atenol Quesada
  • Atenol Stada
  • Atenol Tika
  • Atenol Trom
  • Atenol von ct
  • Atenol-Mepha
  • Atenol-ratiopharm
  • Atenol-Wolff
  • Atenolin
  • Atenolol
  • Atenololum
  • Atenololum [INN-Latin]
  • Atenomel
  • Atereal
  • Aterol
  • Benzeneacetamide, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-
  • Betablok
  • Betacard
  • Betasyn
  • Betatop Ge
  • Blocotenol
  • Blokium
  • BRN 2739235
  • Cardaxen
  • Cardiopress
  • CCRIS 4196
  • Corotenol
  • Cuxanorm
  • dl-Atenolol
  • Duraatenolol
  • EINECS 249-451-7
  • EINECS 262-544-7
  • Evitocor
  • Farnormin
  • Felo-Bits
  • Hipres
  • HSDB 6526
  • Hypoten
  • Ibinolo
  • ICI 66,082
  • ICI 66082
  • Internolol
  • Jenatenol
  • Juvental
  • Lo-ten
  • Loten
  • Lotenal
  • Myocord
  • Normalol
  • Normiten
  • Noten
  • Oraday
  • Ormidol
  • Panapres
  • Plenacor
  • Premorine
  • Prenolol
  • Prenormine
  • Prinorm
  • Scheinpharm Atenol
  • Seles beta
  • Selobloc
  • Serten
  • Servitenol
  • Stermin
  • Tenidon
  • Tenobloc
  • Tenoblock
  • Tenolol
  • Tenoprin
  • Tenormin
  • Tenormine
  • Tenormine [French]
  • Tensimin
  • Tredol
  • Unibloc
  • UNII-50VV3VW0TI
  • Uniloc
  • Vascoten
  • Vericordin
  • Wesipin
  • Xaten

Systematic Names

  • Acetamide, 2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-
  • Atenolol
  • Benzeneacetamide, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-

Superlist Name

  • Atenolol

Mixture Name

  • Tenoretic

Registry Numbers

CAS Registry Number

  • 29122-68-7

FDA UNII

  • 50VV3VW0TI

Other Registry Numbers

  • 106020-65-9
  • 60966-51-0

System Generated Number

  • 0029122687

Structure Descriptors

InChI

1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)

InChIKey

METKIMKYRPQLGS-UHFFFAOYSA-N

Smiles

c1(ccc(cc1)CC(=O)N)OCC(CNC(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 10204ug/kg (10.204mg/kg) BEHAVIORAL: COMA

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Anesthesiology. Vol. 83, Pg. 204, 1995.
man TDLo oral 49mg/kg/30D-I (49mg/kg) BEHAVIORAL: EXCITEMENT Journal of Clinical Pyschopharmacology. Vol. 6, Pg. 390, 1986.
man TDLo oral 86mg/kg/60D-I (86mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" American Journal of Medicine. Vol. 85, Pg. 586, 1988.
man TDLo oral 129mg/kg/26W- (129mg/kg) LUNGS, THORAX, OR RESPIRATION: COUGH

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS
Annales de Medecine Interne. Vol. 148, Pg. 505, 1997.
mouse LD50 intraperitoneal 134mg/kg (134mg/kg)   Toksikologicheskii Vestnik. Vol. (4), Pg. 33, 1995.
mouse LD50 intravenous 57mg/kg (57mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
mouse LD50 oral 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
mouse LD50 subcutaneous > 400mg/kg (400mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
rabbit LD50 intravenous 50mg/kg (50mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 17, Pg. 425, 1979.
rat LD50 intravenous 77mg/kg (77mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
rat LD50 intravenous 84mg/kg (84mg/kg)   PCT Vol. #91-10428,
rat LD50 oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
rat LD50 subcutaneous > 600mg/kg (600mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4579, 1980.
women TDLo oral 16mg/kg (16mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION Annals of Emergency Medicine. Vol. 14, Pg. 161, 1985.
women TDLo oral 42mg/kg/3W-I (42mg/kg)   British Medical Journal. Vol. 294, Pg. 1324, 1987.
women TDLo oral 1080mg/kg/78W (1080mg/kg) MUSCULOSKELETAL: OTHER CHANGES

BLOOD: LEUKOPENIA

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Journal of Rheumatology. Vol. 13, Pg. 446, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 147 deg C   EXP
log P (octanol-water) 0.16 (none)   EXP
Water Solubility 1.33E+04 mg/L 25 EXP
Vapor Pressure 2.92E-10 mm Hg 25 EST
Henry's Law Constant 1.37E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.38E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.