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Substance Name: Ethyl loflazepate [INN:JAN]
RN: 29177-84-2
UNII: VJB5FW9W9J
InChIKey: CUCHJCMWNFEYOM-UHFFFAOYSA-N

Molecular Formula

  • C18-H14-Cl-F-N2-O3

Molecular Weight

  • 360.771
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Ethyl loflazepate
  • Ethyl loflazepate [INN:JAN]

Synonyms

  • 5-25-08-00124 (Beilstein Handbook Reference)
  • BRN 0765264
  • CM 6912
  • EINECS 249-489-4
  • Ethyl 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate
  • Ethyl fluclozepate
  • Ethyl loflazepate
  • Ethylis loflazepas
  • Ethylis loflazepas [INN-Latin]
  • Loflazepate d'ethyle
  • Loflazepate d'ethyle [INN-French]
  • Loflazepato de etilo
  • Loflazepato de etilo [INN-Spanish]
  • Loflazepic acid, ethyl ester
  • UNII-VJB5FW9W9J
  • Victan

Systematic Names

  • 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-, ethyl ester
  • Ethyl 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate
  • Ethyl loflazepate

Superlist Names

  • DEA No. 2758
  • Ethyl loflazepate

Registry Numbers

CAS Registry Number

  • 29177-84-2

FDA UNII

  • VJB5FW9W9J

System Generated Number

  • 0029177842

Structure Descriptors

InChI

1S/C18H14ClFN2O3/c1-2-25-18(24)16-17(23)21-14-8-7-10(19)9-12(14)15(22-16)11-5-3-4-6-13(11)20/h3-9,16H,2H2,1H3,(H,21,23)

InChIKey

CUCHJCMWNFEYOM-UHFFFAOYSA-N

Smiles

C=1(c2c(NC([C@@H](N1)C(OCC)=O)=O)ccc(c2)Cl)c1c(cccc1)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: SLEEP

BEHAVIORAL: MUSCLE WEAKNESS
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 1503, 1986.
mouse LD50 intraperitoneal 712mg/kg (712mg/kg) BEHAVIORAL: ANTIPSYCHOTIC International Journal of Clinical Pharmacology, Therapy and Toxicology. Vol. 19, Pg. 453, 1981.
mouse LD50 oral 5506mg/kg (5506mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 1411, 1986.
mouse LD50 subcutaneous 1795mg/kg (1795mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 1411, 1986.
rat LD50 intraperitoneal 645mg/kg (645mg/kg) BEHAVIORAL: ANTIPSYCHOTIC International Journal of Clinical Pharmacology, Therapy and Toxicology. Vol. 19, Pg. 453, 1981.
rat LD50 oral > 10gm/kg (10000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 1411, 1986.
rat LD50 subcutaneous 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 1411, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 193.5 deg C   EXP
log P (octanol-water) 2.470 (none)   EST
Atmospheric OH Rate Constant 9.39E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.