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Substance Name: Chlorpyrifos [ANSI:BSI:ISO]
RN: 2921-88-2
UNII: JCS58I644W
InChIKey: SBPBAQFWLVIOKP-UHFFFAOYSA-N

Note

  • An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.

Molecular Formula

  • C9-H11-Cl3-N-O3-P-S

Molecular Weight

  • 350.5889
 

Classification Codes

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Insecticide
  • Insecticides
  • Mutation Data
  • Neurotransmitter Agents
  • Pesticides
  • Reproductive Effect

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 127
  • 2011 CERCLA Priority List, Rank: 65
  • Reportable Quantity (RQ) = 1 lb
  • TWA 0.1 mg/m3 inhalable fraction, vapor and aerosol; skin; Not classifiable as a human carcinogen; BEI

Names and Synonyms

Results Name

  • Chlorpyrifos [ANSI:BSI:ISO]

Name of Substance

  • Chlorpyrifos
  • Chlorpyrifos [ANSI:BSI:ISO]
  • Chlorpyrifos [BAN]

MeSH Heading

  • Chlorpyrifos

Synonyms

  • 2-Pyridinol, 3,5,6-trichloro-, O-ester with O,O-diethyl phosphorothioate
  • AI3-27311
  • Bonidel
  • BRN 1545756
  • Brodan
  • Caswell No. 219AA
  • CCRIS 7144
  • Chlorpyrifos
  • Chlorpyrifos ethyl
  • Chlorpyrifos-ethyl
  • Chlorpyriphos
  • Chlorpyriphos [ISO-French]
  • Chlorpyriphos-ethyl
  • Coroban
  • Danusban
  • Detmol U.A.
  • Detmol ua
  • Dhanusban
  • Dowco 179
  • Durmet
  • Dursban
  • Dursban 10CR
  • Dursban 44
  • Dursban 4E
  • Dursban F
  • Dursban R
  • EINECS 220-864-4
  • ENT 27311
  • EPA Pesticide Chemical Code 059101
  • Equity
  • Ethyl chlorpyriphos
  • Geodinfos
  • Grofo
  • HSDB 389
  • Killmaster
  • Lentrek
  • Lock-On
  • Lorsban
  • Lorsban 50SL
  • O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat
  • O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat [German]
  • O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl)phosphorothioate
  • O,O-Diethyl O-(3,5,6-trichloro-2-pyridyl) phsophorothioate
  • O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
  • OMS-0971
  • Piridane
  • Pyrinex
  • Radar
  • Radar (fungicide)
  • Spannit
  • Stipend
  • Suscon
  • suSCon Blue
  • suSCon Green
  • Tafaban
  • Terial
  • Terial 40L
  • Trichlorpyrphos
  • UNII-JCS58I644W
  • XRM 429
  • XRM 5160
  • Zidil

Systematic Names

  • Chlorpyrifos
  • O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
  • Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
  • Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) ester

Superlist Names

  • Chlorpyrifos
  • Chlorpyriphos

Registry Numbers

CAS Registry Number

  • 2921-88-2

FDA UNII

  • JCS58I644W

Other Registry Numbers

  • 12768-48-8
  • 39475-55-3

System Generated Number

  • 0002921882

Structure Descriptors

InChI

1S/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3

InChIKey

SBPBAQFWLVIOKP-UHFFFAOYSA-N

Smiles

CCOP(=S)(OCC)Oc1c(cc(c(n1)Cl)Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 5mg/kg (5mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
chicken LD50 oral 25400ug/kg (25.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967.
duck LD50 oral 76mg/kg (76mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
guinea pig LD50 oral 504mg/kg (504mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C74, 1991.
guinea pig LDLo subcutaneous 100mg/kg (100mg/kg)   Journal of Economic Entomology. Vol. 60, Pg. 733, 1967.
mammal (species unspecified) LD50 unreported 163mg/kg (163mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 712, 1979.
man TDLo oral 300mg/kg (300mg/kg) BEHAVIORAL: COMA

PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: MUSCLE WEAKNESS
Archives of Toxicology. Vol. 59, Pg. 176, 1986.
mouse LD50 intraperitoneal 192mg/kg (192mg/kg)   Toxicology and Applied Pharmacology. Vol. 65, Pg. 144, 1982.
mouse LD50 oral 60mg/kg (60mg/kg)   Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. Vol. 13, Pg. 11, 1978.
mouse LD50 skin 120mg/kg (120mg/kg)   Yakkyoku. Pharmacy. Vol. 38, Pg. 745, 1987.
pigeon LD50 oral 10mg/kg (10mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
quail LD50 oral 13300ug/kg (13.3mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
rabbit LD50 oral 1gm/kg (1000mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 45, 1978.
rabbit LD50 skin 2gm/kg (2000mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 203, 1973.
rat LC50 inhalation > 200mg/m3/4H (200mg/m3)   Pesticide Manual. Vol. 9, Pg. 166, 1991.
rat LD50 oral 82mg/kg (82mg/kg)   Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.
rat LD50 skin 202mg/kg (202mg/kg)   Toxicology and Applied Pharmacology. Vol. 14, Pg. 515, 1969.
rat LD50 unreported 150mg/kg (150mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 339, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 42 deg C   EXP
log P (octanol-water) 4.96 (none)   EXP
Water Solubility 1.12 mg/L 24 EXP
Vapor Pressure 2.03E-05 mm Hg 25 EXP
Henry's Law Constant 2.93E-06 atm-m3/mole 20 EXP
Atmospheric OH Rate Constant 9.17E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.