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Substance Name: Mequitazine [INN:BAN:DCF:JAN]
RN: 29216-28-2
UNII: Y463242LY2
InChIKey: HOKDBMAJZXIPGC-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
  • Reproductive Effect

Molecular Formula

  • C20-H22-N2-S

Molecular Weight

  • 322.4738
 
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Names and Synonyms

Name of Substance

  • Mequitazine
  • Mequitazine [INN:BAN:DCF:JAN]

Synonyms

  • 10-(3-Quinuclidinylmethyl)phenothiazine
  • BRN 1150945
  • EINECS 249-521-7
  • Instotal
  • LM 209
  • LM-209
  • Mequitazina
  • Mequitazina [INN-Spanish]
  • Mequitazina [Spanish]
  • Mequitazine
  • Mequitazinum
  • Mequitazinum [INN-Latin]
  • Metaplexan
  • Mircol
  • NSC 303612
  • Primalan
  • UNII-Y463242LY2
  • Vigigan
  • Virginan

Systematic Names

  • 10-(3-Quinuclidinylmethyl)phenothiazine
  • 10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)- (9CI)
  • 3-Methylquinuclidinyl-10-phenothiazine
  • Mequitazine
  • Phenothiazine, 10-(3-quinuclidinylmethyl)-

Registry Numbers

CAS Registry Number

  • 29216-28-2

FDA UNII

  • Y463242LY2

Related Registry Number

  • 84992-84-7 (hydrochloride)

System Generated Number

  • 0029216282

Structure Descriptors

InChI

1S/C20H22N2S/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2

InChIKey

HOKDBMAJZXIPGC-UHFFFAOYSA-N

Smiles

C(C1CN2CCC1CC2)N3c4ccccc4Sc5ccccc35

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 54mg/kg (54mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 491, 1981.
mouse LD50 oral 210mg/kg (210mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 491, 1981.
mouse LD50 subcutaneous 278mg/kg (278mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 491, 1981.
rat LD50 intraperitoneal 54mg/kg (54mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 491, 1981.
rat LD50 oral 245mg/kg (245mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 491, 1981.
rat LD50 subcutaneous 690mg/kg (690mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 22, Pg. 491, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 130.5 deg C   EXP
log P (octanol-water) 5.660 (none)   EST
Atmospheric OH Rate Constant 2.39E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.