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Substance Name: Toliprolol [INN]
RN: 2933-94-0
UNII: DCP58J201D
InChIKey: NXQMNKUGGYNLBY-UHFFFAOYSA-N

Note

  • Beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H21-N-O2

Molecular Weight

  • 223.314
 
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Names and Synonyms

Name of Substance

  • Toliprolol
  • Toliprolol [INN]

Synonyms

  • 1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol
  • BRN 1874722
  • EINECS 220-905-6
  • ICI 45763 [as hydrochloride]
  • Isopropylamino-1-m-tolyloxy-3-propan-2-ol
  • Isopropylamino-1-m-tolyloxy-3-propan-2-ol [German]
  • Ko 592 [as hydrochloride]
  • MHIP
  • Toliprolol
  • Toliprololum
  • Toliprololum [INN-Latin]
  • UNII-DCP58J201D

Systematic Names

  • 1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol
  • 2-Propanol, 1-((1-methylethyl)amino)-3-(3-methylphenoxy)- (9CI)
  • 2-Propanol, 1-(isopropylamino)-3-(m-tolyloxy)-
  • Toliprolol

Registry Numbers

CAS Registry Number

  • 2933-94-0

FDA UNII

  • DCP58J201D

System Generated Number

  • 0002933940

Structure Descriptors

InChI

1S/C13H21NO2/c1-10(2)14-8-12(15)9-16-13-6-4-5-11(3)7-13/h4-7,10,12,14-15H,8-9H2,1-3H3

InChIKey

NXQMNKUGGYNLBY-UHFFFAOYSA-N

Smiles

c1(cc(ccc1)C)OC[C@@H](CNC(C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 28200ug/kg (28.2mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 869, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 76 deg C   EXP
log P (octanol-water) 1.970 (none)   EST
Atmospheric OH Rate Constant 1.66E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.