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Substance Name: 6-Selenoguanosine
RN: 29411-74-3
InChIKey: JEWAOLSIJOZQMU-UUOKFMHZSA-N

Note

  • Potential antineoplastic agent; analog of 6-thioguanosine with slightly superior therapeutic index.

Molecular Formula

  • C10-H13-N5-O4-Se

Molecular Weight

  • 346.204
 
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Names and Synonyms

Name of Substance

  • 6-Selenoguanosine

Synonyms

  • 6-Selenoguanosine
  • 9H-Purine-6(1H)-one, 2-amino-9-beta-D-ribofuranosyl-6-seleno-
  • NSC 137679

Systematic Names

  • 9H-Purin-6(1H)-one, 2-amino-9-beta-D-ribofuranosyl-6-seleno-
  • Guanosine, 6-seleno- (9CI)

Registry Numbers

CAS Registry Number

  • 29411-74-3

System Generated Number

  • 0029411743

Structure Descriptors

InChI

1S/C10H13N5O4Se/c11-10-13-7-4(8(20)14-10)12-2-15(7)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,20)/t3-,5-,6-,9-/m1/s1

InChIKey

JEWAOLSIJOZQMU-UUOKFMHZSA-N

Smiles

O1[C@H]([C@H](O)[C@@H](O)[C@H]1CO)n1c2c(c(nc([nH]2)N)=[Se])nc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 126mg/kg (126mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 oral 137mg/kg (137mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 subcutaneous 58840ug/kg (58.84mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,