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Substance Name: Bentazepam [USAN:INN]
RN: 29462-18-8
UNII: 66JKK43S1Z
InChIKey: AIZFEOPQVZBNGH-UHFFFAOYSA-N

Classification Codes

  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Hypnotics and Sedatives
  • Sedative-Hypnotic

Molecular Formula

  • C17-H16-N2-O-S

Molecular Weight

  • 296.3924
 
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Names and Synonyms

Name of Substance

  • Bentazepam
  • Bentazepam [USAN:INN]

Synonyms

  • 1,3,6,7,8,9-Hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one
  • 2H-(1)Benzothieno(2,3-e)-1,4-diazepin-2-one, 1,3,6,7,8,9-hexahydro-5-phenyl-
  • 6,7-Tetramethylene-5-phenyl-1,2-dihydro-3H-thieno(2,3-e)(1,4)diazepin-2-one
  • Bentazepam
  • Bentazepamum
  • Bentazepamum [INN-Latin]
  • BRN 1083088
  • CI 718
  • CI-718
  • QM-6008
  • Thiadipone
  • Tiadipone
  • UNII-66JKK43S1Z

Systematic Names

  • 1,3,6,7,8,9-Hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one
  • 2H-(1)Benzothieno(2,3-e)-1,4-diazepin-2-one, 1,3,6,7,8,9-hexahydro-5-phenyl-

Registry Numbers

CAS Registry Number

  • 29462-18-8

FDA UNII

  • 66JKK43S1Z

System Generated Number

  • 0029462188

Structure Descriptors

InChI

1S/C17H16N2OS/c20-14-10-18-16(11-6-2-1-3-7-11)15-12-8-4-5-9-13(12)21-17(15)19-14/h1-3,6-7H,4-5,8-10H2,(H,19,20)

InChIKey

AIZFEOPQVZBNGH-UHFFFAOYSA-N

Smiles

c1ccc(cc1)C2=NCC(=O)Nc3c2c4c(s3)CCCC4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 129mg/kg/17W- (129mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

BEHAVIORAL: MUSCLE WEAKNESS

LIVER: LIVER FUNCTION TESTS IMPAIRED
Lancet. Vol. 343, Pg. 860, 1994.
mouse LD50 intraperitoneal 630mg/kg (630mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 926, 1975.
mouse LD50 oral 980mg/kg (980mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 926, 1975.
rat LD50 oral 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 926, 1975.
women TDLo oral 84mg/kg/8W-I (84mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Journal of Clinical Gastroenterology. Vol. 25, Pg. 710, 1997.