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Substance Name: 2-Aminotetralin
RN: 2954-50-9
InChIKey: JRZGPXSSNPTNMA-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
  • Skin / Eye Irritant

Molecular Formula

  • C10-H13-N

Molecular Weight

  • 147.22
 
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Names and Synonyms

Name of Substance

  • 2-Aminotetralin

Synonyms

  • 1,2,3,4-Tetrahydro-2-naphthylamine
  • 2-Amino-1,2,3,4-tetrahydronaftalen
  • 2-Amino-1,2,3,4-tetrahydronaftalen [Czech]
  • 2-Aminotetralin
  • 4-12-00-02943 (Beilstein Handbook Reference)
  • Aminotetralin
  • Aminotetralin [Czech]
  • beta-1,2,3,4-Tetrahydronaphthylamine
  • BRN 1102357
  • EINECS 220-973-7
  • Tetrahydro-beta-naphthylamine
  • THN

Systematic Names

  • 1,2,3,4-Tetrahydro-2-naphthylamine
  • 2-Naphthylamine, 1,2,3,4-tetrahydro-

Registry Numbers

CAS Registry Number

  • 2954-50-9

Related Registry Number

  • 1743-01-7 (hydrochloride)

System Generated Number

  • 0002954509

Structure Descriptors

InChI

1S/C10H13N/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7,11H2

InChIKey

JRZGPXSSNPTNMA-UHFFFAOYSA-N

Smiles

c12c([C@@H](CCC1)N)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 10mg/kg (10mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR CONSTRICTION

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 70, 1928.
frog LDLo subcutaneous 375mg/kg (375mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. Vol. 115, Pg. 14, 1889.
human TDLo parenteral 10mg/kg (10mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. Vol. 115, Pg. 14, 1889.
human TDLo subcutaneous 10mg/kg (10mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SLEEP

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. Vol. 115, Pg. 14, 1889.
mouse LD50 subcutaneous 64mg/kg (64mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 61, Pg. 168, 1965.
rabbit LDLo intravenous 20mg/kg (20mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 61, Pg. 168, 1965.
rabbit LDLo subcutaneous 50mg/kg (50mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS
Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. Vol. 115, Pg. 14, 1889.

Physical Properties

Physical Property Value Units Temp (deg C) Source
pKa Dissociation Constant 9.93 (none) 17 EXP
log P (octanol-water) 2.08 (none)   EXP
Water Solubility 1.33E+04 mg/L 25 EST
Vapor Pressure 0.020 mm Hg 25 EST
Henry's Law Constant 5.24E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.79E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.