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Substance Name: Prazepam [USAN:USP:INN:BAN:JAN]
RN: 2955-38-6
UNII: Q30VCC064M
InChIKey: MWQCHHACWWAQLJ-UHFFFAOYSA-N

Note

  • A benzodiazepine that is used in the treatment of ANXIETY DISORDERS.

Molecular Formula

  • C19-H17-Cl-N2-O

Molecular Weight

  • 324.8093
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Sedative-Hypnotic
  • Tranquilizing Agents
  • Tumor Data

Superlist Classification Codes

  • DEA Schedule IV
  • Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms

Name of Substance

  • Prazepam
  • Prazepam [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Prazepam

Synonyms

  • 5-24-04-00304 (Beilstein Handbook Reference)
  • 7-Chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-1-cyclopropylmethyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
  • BRN 0895797
  • Centrax
  • Demetrin
  • EINECS 220-975-8
  • K-373
  • Lysanxia
  • NSC 277179
  • Prazepam
  • Prazepamum
  • Prazepamum [INN-Latin]
  • Trepidan
  • UNII-Q30VCC064M
  • Verstran
  • W 4020

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(cyclopropylmethyl)-5-phenyl-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-1,3-dihydro-5-phenyl-
  • Prazepam

Superlist Names

  • DEA No. 2764
  • Prazepam

Registry Numbers

CAS Registry Number

  • 2955-38-6

FDA UNII

  • Q30VCC064M

System Generated Number

  • 0002955386

Structure Descriptors

InChI

1S/C19H17ClN2O/c20-15-8-9-17-16(10-15)19(14-4-2-1-3-5-14)21-11-18(23)22(17)12-13-6-7-13/h1-5,8-10,13H,6-7,11-12H2

InChIKey

MWQCHHACWWAQLJ-UHFFFAOYSA-N

Smiles

c12c(C(=NCC(=O)N1CC1CC1)c1ccccc1)cc(cc2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 759, 1978.
mouse LD50 intraperitoneal 1020mg/kg (1020mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
mouse LD50 intraperitoneal 1020mg/kg (1020mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
mouse LD50 oral 2300mg/kg (2300mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #79-92631,
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 oral > 4gm/kg (4000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 oral > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 145-146 deg C   EXP
log P (octanol-water) 3.73 (none)   EXP
Water Solubility 5.720 mg/L 25 EST
Vapor Pressure 2.14E-09 mm Hg 25 EST
Henry's Law Constant 3.76E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.42E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.