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Substance Name: Parathion-methyl [BSI:ISO]
RN: 298-00-0
UNII: 41BCL2O91D
InChIKey: RLBIQVVOMOPOHC-UHFFFAOYSA-N

Note

  • The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.

Molecular Formula

  • C8-H10-N-O5-P-S

Molecular Weight

  • 263.209
 

Classification Codes

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Fungicide, Bactericide, Wood Preservative
  • Insecticide
  • Insecticides
  • Mutation Data
  • Neurotransmitter Agents
  • Pesticides
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 264
  • Overall Carcinogenic Evaluation: Group 3
  • Reportable Quantity (RQ) = 100 lb
  • Threshold Planning Quantity (TPQ) = 100/10000 lb
  • TWA 0.2 mg/m3; skin; Not classifiable as a human carcinogen; BEI

Names and Synonyms

Results Name

  • Parathion-methyl [BSI:ISO]

Name of Substance

  • Methyl parathion
  • Parathion-methyl [BSI:ISO]

MeSH Heading

  • Methyl parathion

Synonyms

  • 4-06-00-01336 (Beilstein Handbook Reference)
  • 8056HC
  • A-GRO
  • AI3-17292
  • Azofos
  • Azophos
  • BAY 11405
  • BAY E-601
  • Bladan-M
  • BRN 1914724
  • Caswell No. 372
  • CCRIS 405
  • Cekumethion
  • Dalf
  • Demethylfenitrothion
  • Devithion
  • Dimethyl 4-nitrophenyl phosphorothionate
  • Dimethyl p-nitrophenyl monothiophosphate
  • Dimethyl p-nitrophenyl phosphorothionate
  • Dimethyl p-nitrophenyl thiophosphate
  • Dimethyl parathion
  • Dimethyl-p-nitrophenyl thionphosphate
  • Drexel methyl parathion 4E
  • E 601
  • EINECS 206-050-1
  • ENT 17,292
  • EPA Pesticide Chemical Code 053501
  • EPA Shaughnessy Code: 053501
  • Folidol 600
  • Folidol M
  • Folidol M 50
  • Folidol M-40
  • Folidol-80
  • Fosferno M 50
  • HSDB 1168
  • Kilex parathion
  • M-Parathion
  • M40 & 80
  • ME 605
  • Me 605SP
  • Me-parathion
  • Mepaton
  • Meptox
  • Metacid 50
  • Metacide
  • Metacide (insecticide)
  • Metafos
  • Metafos (pesticide)
  • Metaphos
  • Methyl 1605
  • Methyl fosferno
  • Methyl niran
  • Methyl parathion
  • Methyl-E 605
  • Methylparathion
  • Methylthiophos
  • Metilparation (Hungarian)
  • Metron
  • Metron (pesticide)
  • Metyloparation
  • Metyloparation [Polish]
  • Metylparation
  • Metylparation [Czech]
  • NCI-C02971
  • Nitrox
  • Nitrox 80
  • O,O-Dimethyl O-(p-nitrophenyl) phosphorothioate
  • O,O-Dimethyl O-(p-nitrophenyl) thionophosphate
  • O,O-Dimethyl O-p-nitrophenyl thiophosphate
  • O,O-Dimethyl-O-(4-nitro-fenyl)-monothiofosfaat
  • O,O-Dimethyl-O-(4-nitro-fenyl)-monothiofosfaat [Dutch]
  • O,O-Dimethyl-O-(4-nitro-phenyl)-monothiophosphat
  • O,O-Dimethyl-O-(4-nitro-phenyl)-monothiophosphat [German]
  • O,O-Dimethyl-O-(4-nitrophenyl) phosphorothioate
  • O,O-Dimethyl-O-(4-nitrophenyl)-thionophosphat
  • O,O-Dimethyl-O-(4-nitrophenyl)-thionophosphat [German]
  • O,O-Dimethyl-O-(p-nitrophenyl)-thionophosphat
  • O,O-Dimethyl-O-(p-nitrophenyl)-thionophosphat [German]
  • O,O-Dimethyl-O-p-nitrofenylester kyseliny thiofosforecne
  • O,O-Dimethyl-O-p-nitrofenylester kyseliny thiofosforecne [Czech]
  • O,O-Dimethyl-O-p-nitrofenylthiofosfat
  • O,O-Dimethyl-O-p-nitrofenylthiofosfat [Czech]
  • O,O-Dimetil-O-(4-nitro-fenil)-monotiofosfato
  • O,O-Dimetil-O-(4-nitro-fenil)-monotiofosfato [Italian]
  • Oleovofotox
  • p-Nitrophenyldimethylthionophosphate
  • Parapest M-50
  • Parathion methyl
  • Parathion methyl homolog
  • Parathion-methyl
  • Parathion-metile
  • Parathion-metile [Italian]
  • Paratox
  • Paratuf
  • Parton-M
  • Partron M
  • Penncap MLS
  • Penncap-M
  • Phenol, p-nitro-, O-ester with O,O-dimethyl phosphorothioate
  • Phenol, p-nitro-, O-ester with O,O-dimethylphosphorothioate
  • Quinophos
  • RCRA waste number P071
  • Sinafid M-48
  • Tekwaisa
  • Thiophenit
  • Thiophosphate de O,O-dimethyle et de O-(4-nitrophenyle)
  • Thiophosphate de O,O-dimethyle et de O-(4-nitrophenyle) [French]
  • Thylpar M-50
  • UNII-41BCL2O91D
  • Vofatox
  • Wofatox
  • Wofatox 50 EC
  • Wofatox 80
  • Yphos

Systematic Names

  • Methyl parathion
  • Parathion-methyl
  • Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester
  • Phosphorothioic acid, O,O-dimethyl O-(p-nitrophenyl) ester

Superlist Names

  • Methyl parathion
  • Methyl parathion, liquid
  • Methyl parathion, liquid [NA3018] [Poison]
  • Methyl parathion, solid
  • Methyl parathion, solid [NA2783] [Poison]
  • NA2783
  • NA3018
  • Parathion-methyl
  • Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester
  • RCRA waste no. P071

Registry Numbers

CAS Registry Number

  • 298-00-0

FDA UNII

  • 41BCL2O91D

Other Registry Numbers

  • 37359-35-6
  • 63653-66-7

System Generated Number

  • 0000298000

Structure Descriptors

InChI

1S/C8H10NO5PS/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3

InChIKey

RLBIQVVOMOPOHC-UHFFFAOYSA-N

Smiles

COP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 5mg/kg (5mg/kg)   Journal de Toxicologie Clinique et Experimentale. Vol. 6(3), Pg. 175, 1986.
dog LD50 oral 90mg/kg (90mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Proceedings of the European Society of Toxicology. Vol. 16, Pg. 273, 1975.
duck LD50 oral 10mg/kg (10mg/kg)   Down to Earth. Vol. 35, Pg. 25, 1979.
duck LD50 skin 54mg/kg (54mg/kg)   Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979.
guinea pig LD50 intravenous 50mg/kg (50mg/kg)   National Technical Information Service. Vol. PB241-840,
guinea pig LD50 oral 1270mg/kg (1270mg/kg)   National Technical Information Service. Vol. PB241-840,
mammal (species unspecified) LD50 oral 57mg/kg (57mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. PB288-416,
mammal (species unspecified) LD50 unreported 25mg/kg (25mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 327, 1971.
mouse LC50 inhalation 120mg/m3/4H (120mg/m3)   National Technical Information Service. Vol. PB241-840,
mouse LD50 intracrebral 47mg/kg (47mg/kg)   Pesticide Biochemistry and Physiology. Vol. 8, Pg. 302, 1978.
mouse LD50 intraperitoneal 5400ug/kg (5.4mg/kg)   Pesticide Biochemistry and Physiology. Vol. 8, Pg. 302, 1978.
mouse LD50 intravenous 9800ug/kg (9.8mg/kg)   National Technical Information Service. Vol. PB241-840,
mouse LD50 oral 17800ug/kg (17.8mg/kg)   Human & Experimental Toxicology. Vol. 11, Pg. 11, 1992.
mouse LD50 skin 1200mg/kg (1200mg/kg)   Journal of Toxicology and Environmental Health. Vol. 9, Pg. 491, 1982.
mouse LD50 subcutaneous 18mg/kg (18mg/kg)   Bratislavske Lekarske Listy. Vol. 38, Pg. 151, 1958.
mouse LD50 unreported 23mg/kg (23mg/kg)   Bulletin of the World Health Organization. Vol. 44, Pg. 31, 1971.
rabbit LD50 oral 420mg/kg (420mg/kg)   National Technical Information Service. Vol. PB241-840,
rabbit LD50 skin 300mg/kg (300mg/kg)   Quarterly Bulletin--Association of Food and Drug Officials of the United States. Vol. 16, Pg. 3, 1952.
rat LC50 inhalation 34mg/m3/4H (34mg/m3) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Egeszsegtudomany. Vol. 24, Pg. 173, 1980.
rat LD50 intraperitoneal 2800ug/kg (2.8mg/kg)   Advances in Pest Control Research. Vol. 4, Pg. 117, 1961.
rat LD50 intravenous 9mg/kg (9mg/kg)   National Technical Information Service. Vol. PB277-077,
rat LD50 oral 6010ug/kg (6.01mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1155, 1986.
rat LD50 skin 67mg/kg (67mg/kg)   World Review of Pest Control. Vol. 4, Pg. 36, 1965.
rat LD50 subcutaneous 6mg/kg (6mg/kg)   Journal of Economic Entomology. Vol. 50, Pg. 356, 1957.
rat LD50 unreported 10mg/kg (10mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 74, Pg. 41P, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 35.5 deg C   EXP
pKa Dissociation Constant 7.15 (none)   EXP
log P (octanol-water) 2.86 (none)   EXP
Water Solubility 37.7 mg/L 20 EXP
Vapor Pressure 3.50E-06 mm Hg 25 EXP
Henry's Law Constant 1.00E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 5.90E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.