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Substance Name: Nitroblue tetrazolium
RN: 298-83-9
UNII: X44P41F7ZK
InChIKey: FSVCQIDHPKZJSO-UHFFFAOYSA-L

Note

  • Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.

Molecular Formula

  • C40-H30-N10-O6.2Cl

Molecular Weight

  • 817.647
 

Classification Codes

  • Indicators and Reagents
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Nitroblue tetrazolium

MeSH Heading

  • Nitroblue tetrazolium

Synonyms

  • CCRIS 9104
  • EINECS 206-067-4
  • NBT
  • NBT (dye)
  • Nitro Blue tetrazolium
  • Nitro Blue tetrazolium chloride
  • Nitro Blue tetrazolium salt
  • Nitro BT
  • Nitro tetrazolium BT
  • Nitroblue tetrazolium salt
  • Nitrotetrazolium Blue
  • Nitrotetrazolium Chloride Blue
  • NSC 27622
  • p-Nitro Blue tetrazolium
  • p-Nitro Blue tetrazolium chloride
  • p-Nitrotetrazolium Blue
  • Tetrazolium Nitro Blue
  • Tetrazolium nitro BT
  • UNII-X44P41F7ZK

Systematic Names

  • 2H-Tetrazolium, 2,2'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(3-(4-nitrophenyl)-5-phenyl-, chloride (1:2)
  • 2H-Tetrazolium, 2,2'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(3-(4-nitrophenyl)-5-phenyl-, dichloride
  • 2H-Tetrazolium, 3,3'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2-(4-nitrophenyl)-5-phenyl-, dichloride
  • 2H-Tetrazolium, 3,3'-(3,3'-dimethoxy(1,1'-biphenyl)-4,4'-diyl)bis(2-(4-nitrophenyl)-5-phenyl-,dichloride
  • 5,5'-Diphenyl-3,3'-bis(4-nitrophenyl)-2,2'-(3,3'-dimethoxybiphenyl-4,4'-ylene)ditetrazolium dichloride

Registry Numbers

CAS Registry Number

  • 298-83-9

FDA UNII

  • X44P41F7ZK

Other Registry Numbers

  • 121287-37-4
  • 1401448-88-1
  • 141102-30-9
  • 1422392-93-5
  • 562102-25-4
  • 67740-22-1
  • 679787-05-4
  • 83800-46-8
  • 867000-48-4
  • 87714-63-4

System Generated Number

  • 0000298839

Molecular Formulas

Molecular Formula

  • C40-H30-N10-O6.2Cl

Molecular Formula Fragments

  • C40-H30-N10-O6
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C40H30N10O6.2ClH/c1-55-37-25-29(13-23-35(37)47-43-39(27-9-5-3-6-10-27)41-45(47)31-15-19-33(20-16-31)49(51)52)30-14-24-36(38(26-30)56-2)48-44-40(28-11-7-4-8-12-28)42-46(48)32-17-21-34(22-18-32)50(53)54;;/h3-26H,1-2H3;2*1H/q+2;;/p-2

InChIKey

FSVCQIDHPKZJSO-UHFFFAOYSA-L

Smiles

COc1cc(ccc1n2nc(n[n+]2c3ccc(cc3)[N+](=O)[O-])c4ccccc4)c5ccc(c(c5)OC)n6nc(n[n+]6c7ccc(cc7)[N+](=O)[O-])c8ccccc8.[Cl-].[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 614, 1990.