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Substance Name: Calcium Gluconate [USAN:JAN]
RN: 299-28-5
UNII: SQE6VB453K
InChIKey: NEEHYRZPVYRGPP-IYEMJOQQSA-L

Note

  • The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.

Molecular Formula

  • C6-H12-O7.1/2Ca

Molecular Weight

  • 430.3698
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Replenisher (Calcium)

Names and Synonyms

Name of Substance

  • Calcium gluconate
  • Calcium Gluconate [USAN:JAN]
  • Gluconic acid, calcium salt

MeSH Heading

  • Calcium gluconate

Synonyms

  • Calcet
  • Calcicol
  • Calciofon
  • Calcipur
  • Calcium D-gluconate
  • Calcium D-gluconate (1:2)
  • Calcium gluconate
  • Calcium hexagluconate
  • Calglucol
  • Calglucon
  • CCRIS 1336
  • D-Gluconic acid, calcium salt (2:1)
  • Dragocal
  • Ebucin
  • EINECS 206-075-8
  • Glucal
  • Glucobiogen
  • Gluconate de calcium
  • Gluconate de calcium [French]
  • Gluconato di calcio
  • Gluconato di calcio [Italian]
  • Gluconic acid, calcium salt (2:1), D-
  • HSDB 994
  • Kalpren
  • Novocal
  • UNII-SQE6VB453K

Systematic Names

  • Calcium gluconate
  • D-Gluconic acid, calcium salt (2:1)

Superlist Name

  • Calcium gluconate

Registry Numbers

CAS Registry Number

  • 299-28-5

FDA UNII

  • SQE6VB453K

Other Registry Numbers

  • 18016-24-5
  • 3414-35-5

System Generated Number

  • 0000299285

Molecular Formulas

Molecular Formula

  • C6-H12-O7.1/2Ca

Molecular Formula Fragments

  • C6-H12-O7
  • Ca
  • COMPONENT

Structure Descriptors

InChI

1S/2C6H12O7.Ca/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1

InChIKey

NEEHYRZPVYRGPP-IYEMJOQQSA-L

Smiles

[Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)[O-].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 1987mg/kg (1987mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 183, 1933.
guinea pig LDLo intravenous 1810mg/kg (1810mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 191, Pg. 44, 1971.
infant LDLo intramuscular 10gm/kg (10000mg/kg) BRAIN AND COVERINGS: MENINGEAL CHANGES

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
JAMA, Journal of the American Medical Association. Vol. 129, Pg. 347, 1945.
infant TDLo intramuscular 143mg/kg (143mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" JAMA, Journal of the American Medical Association. Vol. 129, Pg. 347, 1945.
mouse LD50 intraperitoneal 2200mg/kg (2200mg/kg)   Journal of Drug Research. Vol. 15(1-2), Pg. 121, 1984.
mouse LD50 intravenous 950mg/kg (950mg/kg)   Toxicology and Applied Pharmacology. Vol. 4, Pg. 492, 1962.
mouse LD50 subcutaneous 2890mg/kg (2890mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 47, 1956.
mouse LDLo oral 10gm/kg (10000mg/kg)   Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.
rat LD50 intravenous 950mg/kg (950mg/kg)   Drugs in Japan Vol. 6, Pg. 226, 1982.
rat LDLo oral 10gm/kg (10000mg/kg)   Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -7.510 (none)   EST
Water Solubility 3.33E+04 mg/L   EXP
Atmospheric OH Rate Constant 7.63E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.