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Substance Name: Treosulfan [INN:BAN]
RN: 299-75-2
UNII: CO61ER3EPI
InChIKey: YCPOZVAOBBQLRI-WDSKDSINSA-N

Note

  • Immunosuppressant.

Molecular Formula

  • C6-H14-O8-S2

Molecular Weight

  • 278.3006
 

Classification Codes

Classification Codes

  • Alkylating Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Mutation Data
  • Noxae
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 1
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Names and Synonyms

Name of Substance

  • Treosulfan
  • Treosulfan [INN:BAN]

Synonyms

  • (2S,3S)-Threitol 1,4-bismethanesulfonate
  • CB 2562
  • CB 40067
  • CCRIS 2781
  • DHB
  • Dihydroxybusulfan
  • Dihydroxymyleran
  • EINECS 206-081-0
  • HSDB 6963
  • L-Threitol 1,4-dimethanesulfonate
  • L-Threitol, 1,4-bis(methanesulfonate)
  • l-Threitol-1,4-bis(methanesulfonate)
  • L-Threityl dimesylate
  • NSC 39069
  • NSC-39069
  • Ovastat
  • Threitol, 1,4-dimethanesulfonate, L-(+)-
  • Treosulfan
  • Treosulfano
  • Treosulfano [INN-Spanish]
  • Treosulfanum
  • Treosulfanum [INN-Latin]
  • Treosulphan
  • Tresulfan
  • UNII-CO61ER3EPI

Systematic Names

  • (S-(R*,R*))-1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate
  • 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (S-(R*,R*))-
  • 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (S-(R*,R*))- (9CI)
  • L-Threitol 1,4-dimethanesulfonate
  • L-Threitol, 1,4-bismethanesulfonate
  • Threitol, 1,4-dimethanesulfonate, (2S,3S)- (8CI)
  • Treosulfan
  • Treosulphan

Superlist Names

  • 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (S-(R*,R*))-
  • Treosulfan
  • Treosulphan

Registry Numbers

CAS Registry Number

  • 299-75-2

FDA UNII

  • CO61ER3EPI

Other Registry Numbers

  • 14461-01-9
  • 27863-55-4
  • 5592-88-1

System Generated Number

  • 0000299752

Structure Descriptors

InChI

1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1

InChIKey

YCPOZVAOBBQLRI-WDSKDSINSA-N

Smiles

S(=O)(=O)(OC[C@@H]([C@H](COS(=O)(=O)C)O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 222mg/kg (222mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: LEUKOPENIA

BLOOD: OTHER CHANGES
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
monkey LDLo intravenous 222mg/kg (222mg/kg) BLOOD: LEUKOPENIA

BLOOD: AGRANULOCYTOSIS

BLOOD: OTHER CHANGES
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -3.350 (none)   EST
Water Solubility 1.00E+06 mg/L 25 EST
Vapor Pressure 3.80E-10 mm Hg 25 EST
Henry's Law Constant 6.90E-16 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.30E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.