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Substance Name: Estazolam [USAN:INN:JAN]
RN: 29975-16-4
UNII: 36S3EQV54C
InChIKey: CDCHDCWJMGXXRH-UHFFFAOYSA-N

Note

  • A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.

Molecular Formula

  • C16-H11-Cl-N4

Molecular Weight

  • 294.7439
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Sedative-Hypnotic
  • Tranquilizing Agents
  • Tumor Data

Superlist Classification Codes

  • DEA Schedule IV
  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Estazolam
  • Estazolam [USAN:INN:JAN]

MeSH Heading

  • Estazolam

Synonyms

  • 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
  • 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine
  • 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
  • 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine (IUPAC)
  • Abbott 47631
  • Abbott-47631
  • BRN 1220868
  • CCRIS 1955
  • D 40TA
  • D-40TA
  • EINECS 249-982-4
  • Esilgan
  • Estazolam
  • Estazolamum
  • Estazolamum [INN-Latin]
  • Eurodin
  • Julodin
  • NSC 290818
  • Nuctalon
  • ProSom
  • U 33737
  • UNII-36S3EQV54C

Systematic Names

  • 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
  • 4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
  • Estazolam

Superlist Names

  • DEA No. 2756
  • Estazolam

Registry Numbers

CAS Registry Number

  • 29975-16-4

FDA UNII

  • 36S3EQV54C

System Generated Number

  • 0029975164

Structure Descriptors

InChI

1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

InChIKey

CDCHDCWJMGXXRH-UHFFFAOYSA-N

Smiles

c12c(C(c3ccccc3)=NCc3n1cnn3)cc(Cl)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 593mg/kg (593mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
mouse LD50 intraperitoneal 438mg/kg (438mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: ANTIPSYCHOTIC		 Japanese Journal of Pharmacology. Vol. 21, Pg. 497, 1971.
mouse LD50 oral 600mg/kg (600mg/kg)   Collection of Czechoslovak Chemical Communications. Vol. 48, Pg. 2395, 1983.
mouse LD50 subcutaneous 3170mg/kg (3170mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
rabbit LD50 oral 300mg/kg (300mg/kg)   Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 32, Pg. 152, 1973.
rat LD50 intramuscular 868mg/kg (868mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
rat LD50 intraperitoneal 339mg/kg (339mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
rat LD50 oral 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 103, 1982.
rat LD50 subcutaneous 3580mg/kg (3580mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 228.5 deg C   EXP
log P (octanol-water) 3.320 (none)   EST
Atmospheric OH Rate Constant 7.64E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.