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Substance Name: Estazolam [USAN:INN:JAN]
RN: 29975-16-4
UNII: 36S3EQV54C
InChIKey: CDCHDCWJMGXXRH-UHFFFAOYSA-N
Note
- A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.
Molecular Formula
- C16-H11-Cl-N4
Molecular Weight
- 294.7439
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anti-Anxiety Agents
- Anticonvulsants
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Sedative-Hypnotic
- Tranquilizing Agents
- Tumor Data
Superlist Classification Codes
- DEA Schedule IV
- Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms
Name of Substance
- Estazolam
- Estazolam [USAN:INN:JAN]
MeSH Heading
- Estazolam
Synonyms
- 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
- 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine
- 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
- 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine (IUPAC)
- Abbott 47631
- Abbott-47631
- BRN 1220868
- CCRIS 1955
- D 40TA
- D-40TA
- EINECS 249-982-4
- Esilgan
- Estazolam
- Estazolamum
- Estazolamum [INN-Latin]
- Eurodin
- Julodin
- NSC 290818
- Nuctalon
- ProSom
- U 33737
- UNII-36S3EQV54C
Systematic Names
- 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
- 4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
- Estazolam
Superlist Names
- DEA No. 2756
- Estazolam
Registry Numbers
CAS Registry Number
- 29975-16-4
FDA UNII
- 36S3EQV54C
System Generated Number
- 0029975164
Structure Descriptors
InChI
InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2InChIKey
CDCHDCWJMGXXRH-UHFFFAOYSA-NSmiles
Clc1ccc2c(c1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intramuscular | 593mg/kg (593mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
mouse | LD50 | intraperitoneal | 438mg/kg (438mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: ATAXIA | Japanese Journal of Pharmacology. Vol. 21, Pg. 497, 1971. |
mouse | LD50 | oral | 600mg/kg (600mg/kg) | Collection of Czechoslovak Chemical Communications. Vol. 48, Pg. 2395, 1983. | |
mouse | LD50 | subcutaneous | 3170mg/kg (3170mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
rabbit | LD50 | oral | 300mg/kg (300mg/kg) | Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 32, Pg. 152, 1973. | |
rat | LD50 | intramuscular | 868mg/kg (868mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
rat | LD50 | intraperitoneal | 339mg/kg (339mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. | |
rat | LD50 | oral | 2500mg/kg (2500mg/kg) | Drugs in Japan Vol. 6, Pg. 103, 1982. | |
rat | LD50 | subcutaneous | 3580mg/kg (3580mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 228.5 | deg C | EXP | |
log P (octanol-water) | 3.320 | (none) | EST | |
Atmospheric OH Rate Constant | 7.64E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.