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Substance Name: Methamphetamine hydrochloride, (dl)
RN: 300-42-5
UNII: 24GNZ56D62
InChIKey: TWXDDNPPQUTEOV-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
  • Skin / Eye Irritant

Molecular Formula

  • C10-H15-N.Cl-H

Molecular Weight

  • 185.6964
 
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Names and Synonyms

Name of Substance

  • Methamphetamine hydrochloride, (dl)

Synonyms

  • (+-)-Methamphetamine hydrochloride
  • (+-)-N-Methylamphetamine hydrochloride
  • 914F
  • Amdram
  • Amedrine
  • Amphedroxy
  • Amphedroxyn
  • Bombita
  • C 6379
  • Corvitin
  • Daropervamin
  • DEA oxo-5
  • Deoxyephedrine
  • Depoxin
  • Des-oxa-D
  • Desamine
  • Desfedran
  • Desfedrin
  • Desossiefedrina
  • Desoxedrine
  • Desoxyephedrine hydrochloride
  • Detrex
  • Dexophrine
  • dl-Desoxyephedrine hydrochloride
  • dl-Methamphetamine hydrochloride
  • dl-Methamphetimine hydrochloride
  • Dopidrin
  • Doxephin
  • Doxephrin
  • EINECS 206-093-6
  • EINECS 224-306-0
  • Estimulex
  • Fenyprin
  • Kemodrin
  • Lanazine
  • Levetamin
  • Madrine
  • Mepho-D
  • Metamfetamina
  • Metamphetamin
  • Metamsustac
  • Metanfetamina
  • Methampex
  • Methamphin
  • Methedrinal
  • Methoxyn
  • Methylbenzedrin
  • Methylpropamine
  • Miller drine
  • N,alpha-Dimethylphenethylamine hydrochloride
  • N-Methyl-beta-phenylisopropylaminhydrochlorid
  • N-Methyl-beta-phenylisopropylaminhydrochlorid [German]
  • Neodrine
  • Neopharmedrine
  • Noradrin
  • Normadrine
  • Norodrin
  • NSC 169506
  • NSC 22367
  • Obesin
  • Oxydess
  • Oxydrene
  • Oxydrin
  • Oxyfed
  • Phedoxe
  • Phedrisox
  • Pisichergina
  • Premodrin
  • Psichergina
  • Psicopan
  • Psiquergina
  • Psychergine
  • Psykoton
  • Semoxydrine
  • UNII-24GNZ56D62

Systematic Names

  • Benzeneethanamine, N,alpha-dimethyl-, hydrochloride
  • Benzeneethanamine, N,alpha-dimethyl-, hydrochloride (9CI)
  • N,alpha-Dimethylphenethylamine hydrochloride
  • Phenethylamine, N,alpha-dimethyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 300-42-5

FDA UNII

  • 24GNZ56D62

Other Registry Number

  • 4298-16-2

System Generated Number

  • 0000300425

Molecular Formulas

Molecular Formula

  • C10-H15-N.Cl-H

Molecular Formula Fragments

  • C10-H15-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H

InChIKey

TWXDDNPPQUTEOV-UHFFFAOYSA-N

Smiles

Cl.CNC(C)Cc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 2500ug/kg (2.5mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 115, 1967.
dog LDLo oral 10mg/kg (10mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 158, Pg. 115, 1967.
human TDLo oral 17mg/kg (17mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ANOREXIA (HUMAN
Klinische Wochenscrift. Vol. 17, Pg. 1580, 1938.
mouse LD50 intraperitoneal 4mg/kg (4mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 271, 1961.
mouse LD50 intraperitoneal 57190ug/kg (57.19mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the Association of Official Analytical Chemists. Vol. 68, Pg. 1213, 1985.
mouse LD50 intravenous 15mg/kg (15mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS
Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980.
mouse LD50 oral 15mg/kg (15mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 166, 1974.
mouse LD50 oral 143mg/kg (143mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 223, 1948.
mouse LD50 subcutaneous 9mg/kg (9mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 271, 1961.
rabbit LD50 intramuscular 220mg/kg (220mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rabbit LD50 intravenous 3mg/kg (3mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 3, Pg. 215, 1972.
rabbit LD50 oral 10500ug/kg (10.5mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 3, Pg. 215, 1972.
rabbit LD50 subcutaneous 205mg/kg (205mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 284, 1946.
rat LD50 intraperitoneal 19mg/kg (19mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 708, 1958.
rat LD50 intraperitoneal 54480ug/kg (54.48mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 223, 1948.
rat LD50 intravenous 13mg/kg (13mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980.
rat LD50 oral 29mg/kg (29mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 166, 1974.
rat LD50 subcutaneous 79700ug/kg (79.7mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Japanese Journal of Pharmacology. Vol. 35, Pg. 273, 1984.