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Substance Name: Benactyzine [INN:BAN]
RN: 302-40-9
UNII: 595EG71R3F


  • A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.

Molecular Formula

  • C20-H25-N-O3

Molecular Weight

  • 327.4215

Classification Codes

  • Antidepressive Agents
  • Autonomic Agents
  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Human Data
  • Muscarinic Antagonists
  • Mutation Data
  • Neurotransmitter Agents
  • Parasympatholytics
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
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Names and Synonyms

Name of Substance

  • Benactyzine
  • Benactyzine [INN:BAN]

MeSH Heading

  • Benactyzine


  • 2-(Diethylamino)ethyl benzilate
  • 2-(Diethylamino)ethyl diphenylglycolate
  • 4-10-00-01263 (Beilstein Handbook Reference)
  • alpha-Hydroxy-alpha-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • Benacticina
  • Benacticina [INN-Spanish]
  • Benactizina
  • Benactizina [DCIT]
  • Benactizina [Italian]
  • Benactyzin
  • Benactyzine
  • Benactyzinum
  • Benactyzinum [INN-Latin]
  • Benzactyzine
  • Benzilic acid beta-diethylaminoethyl ester
  • BRN 2156821
  • Diazil
  • Diethylaminoethyl benzilate
  • Diphenylglycolic acid 2-(diethylamino)ethyl ester
  • EINECS 206-123-8
  • HSDB 3292
  • UNII-595EG71R3F

Systematic Names

  • 2-Diethylaminoethyl benzilate
  • Benactyzine
  • Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester (9CI)
  • Benzilic acid, 2-(diethylamino)ethyl ester

Registry Numbers

CAS Registry Number

  • 302-40-9


  • 595EG71R3F

System Generated Number

  • 0000302409

Structure Descriptors








Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intramuscular 100ug/kg (0.1mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
mouse LD50 subcutaneous 159mg/kg (159mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Russian Pharmacology and Toxicology Vol. 32, Pg. 311, 1969.
rat LD50 intramuscular 135mg/kg (135mg/kg)   National Technical Information Service. Vol. AD-A099-745,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 51 deg C   EXP
log P (octanol-water) 2.890 (none)   EST
Atmospheric OH Rate Constant 1.05E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.