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Substance Name: Edrophonium bromide
RN: 302-83-0
UNII: KX008093VW
InChIKey: CAEPIUXAUPYIIJ-UHFFFAOYSA-N

Note

  • A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.

Molecular Formula

  • C10-H16-N-O.Br

Molecular Weight

  • 246.1464
 

Classification Codes

  • Cholinesterase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
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Names and Synonyms

Results Name

  • Edrophonium bromide

Name of Substance

  • Edrophonium bromide

Synonyms

  • 3-Hydroxyphenyldimethylethylammonium bromide
  • Edrophonium bromide
  • Ethyl(m-hydroxyphenyl)dimethylammonium bromide
  • N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium bromide
  • Oedrophanium
  • Ro 2-3198
  • Tensilon bromide
  • UNII-KX008093VW

Systematic Names

  • Ammonium, (3-hydroxyphenyl)dimethylethyl-, bromide
  • Ammonium, ethyl(m-hydroxyphenyl)dimethyl-, bromide (8CI)
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, bromide (9CI)

Registry Numbers

CAS Registry Number

  • 302-83-0

FDA UNII

  • KX008093VW

System Generated Number

  • 0000302830

Molecular Formulas

Molecular Formula

  • C10-H16-N-O.Br

Molecular Formula Fragments

  • Br
  • C10-H16-N-O
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15NO.BrH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H

InChIKey

CAEPIUXAUPYIIJ-UHFFFAOYSA-N

Smiles

[Br-].CC[N+](C)(C)c1cccc(O)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 15mg/kg (15mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 83, 1950.
mouse LD50 intraperitoneal 37mg/kg (37mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 83, 1950.
mouse LD50 intravenous 9mg/kg (9mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 83, 1950.
mouse LD50 oral 600mg/kg (600mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 83, 1950.
mouse LD50 subcutaneous 130mg/kg (130mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 83, 1950.
rabbit LD50 intravenous 28500ug/kg (28.5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 83, 1950.