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Substance Name: Oxitropium bromide [INN:BAN:JAN]
RN: 30286-75-0
UNII: SF4NW7NH7C
InChIKey: LCELQERNWLBPSY-KHSTUMNDSA-M

Classification Codes

  • Autonomic Agents
  • Drug / Therapeutic Agent
  • Parasympatholytics
  • Peripheral Nervous System Agents
  • Reproductive Effect

Molecular Formulas

  • C19-H26-Br-N-O4
  • C19-H26-N-O4.Br

Molecular Weight

  • 412.3214
 
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Names and Synonyms

Name of Substance

  • Oxitropium
  • Oxitropium bromide [INN:BAN:JAN]

Synonyms

  • (-)-N-Ethyl-norhyoscine-methobromide
  • Ba 253
  • Ba 253BR-L
  • Ba-253-BR-L
  • Bromure d'oxitropium
  • Bromuro de oxitropio
  • Bromuro de oxitropio [INN-Spanish]
  • Bromuro de oxitropio [Spanish]
  • EINECS 250-113-6
  • Hyoscine ethobromide
  • N-Ethyl-norscopolamine methobromide
  • Oxitropii bromidum
  • Oxitropii bromidum [INN-Latin]
  • Oxitropio bromuro
  • Oxitropio bromuro [Spanish]
  • Oxitropium
  • Oxitropium bromide
  • Oxivent
  • Oxytropium bromide
  • Scopolamine ethobromide
  • Tersigat
  • UNII-SF4NW7NH7C
  • Ventilat

Systematic Names

  • (8r)-6beta,7beta-Epoxy-8-ethyl-3alpha-hydroxy-1alphaH,5alphaH-tropanium bromide (-)-tropate
  • 3-Oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane, 9-ethyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, (7(S)-(1-alpha,2-beta,4-beta,5-alpha,7-beta))-
  • Oxitropium bromide

Registry Numbers

CAS Registry Number

  • 30286-75-0

FDA UNII

  • SF4NW7NH7C

Other Registry Number

  • 2019-63-8

System Generated Number

  • 0030286750

Molecular Formulas

Molecular Formulas

  • C19-H26-Br-N-O4
  • C19-H26-N-O4.Br

Molecular Formula Fragments

  • Br
  • C19-H26-N-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C19H26NO4.BrH/c1-3-20(2)15-9-13(10-16(20)18-17(15)24-18)23-19(22)14(11-21)12-7-5-4-6-8-12;/h4-8,13-18,21H,3,9-11H2,1-2H3;1H/q+1;/p-1/t13-,14-,15-,16+,17-,18+,20?;/m1./s1

InChIKey

LCELQERNWLBPSY-KHSTUMNDSA-M

Smiles

CC[N+]1([C@@H]2C[C@H](C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)c4ccccc4)C.[Br-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 40mg/kg (40mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 353, 1988.
dog LD50 oral 3gm/kg (3000mg/kg)   Drugs of the Future. Vol. 4, Pg. 117, 1979.
mouse LD50 intravenous 25700ug/kg (25.7mg/kg)   Drugs of the Future. Vol. 4, Pg. 117, 1979.
mouse LD50 oral 1600mg/kg (1600mg/kg)   Drugs of the Future. Vol. 4, Pg. 117, 1979.
mouse LD50 subcutaneous 1150mg/kg (1150mg/kg)   Drugs of the Future. Vol. 4, Pg. 117, 1979.
rabbit LD50 intravenous 34mg/kg (34mg/kg)   Drugs of the Future. Vol. 4, Pg. 117, 1979.
rabbit LD50 oral > 8gm/kg (8000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 435, 1985.
rat LD50 intravenous 19mg/kg (19mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 353, 1988.
rat LD50 oral 2250mg/kg (2250mg/kg)   Drugs of the Future. Vol. 4, Pg. 117, 1979.