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Substance Name: Dasatinib [USAN:INN]
RN: 302962-49-8
UNII: X78UG0A0RN
InChIKey: ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. (NCI Thesaurus)

Molecular Formula

  • C22-H26-Cl-N7-O2-S

Molecular Weight

  • 488.0134
 

Classification Codes

  • Antineoplastic
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors

Names and Synonyms

Results Name

  • Dasatinib [USAN:INN]

Name of Substance

  • Dasatinib
  • Dasatinib [USAN:INN]

Synonyms

  • BMS 354825
  • BMS-354825
  • BMS354825
  • Dasatinib
  • Dasatinib anhydrous
  • N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
  • Sprycel
  • UNII-X78UG0A0RN

Systematic Name

  • 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-

Registry Numbers

CAS Registry Number

  • 302962-49-8

FDA UNII

  • X78UG0A0RN

System Generated Number

  • 0302962498

Structure Descriptors

InChI

1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChIKey

ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Smiles

Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl