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Substance Name: Clinofibrate [INN:JAN]
RN: 30299-08-2
UNII: 0374EZJ8CU
InChIKey: BMOVQUBVGICXQN-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C28-H36-O6

Molecular Weight

  • 468.5864
 
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Names and Synonyms

Name of Substance

  • Clinofibrate
  • Clinofibrate [INN:JAN]

Synonyms

  • 2,2'-(4,4'-Cyclohexylidenediphenoxy)-2,2'-dimethyldibutyric acid
  • 2,2'-(Cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methylbutanoic acid)
  • 2,2'-(Cyclohexylidenebis(p-phenyleneoxy))bis(2-methylbutyric acid)
  • 2,2'-Cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyric acid)
  • 2,2'-Dimethyl-2,2'-(4,4'-cyclohexylidendiphenoxy)dibuttersaeure
  • BRN 2230067
  • Clinofibrate
  • Clinofibrato
  • Clinofibrato [INN-Spanish]
  • Clinofibratum
  • Clinofibratum [INN-Latin]
  • Lipoclin
  • S 8527
  • UNII-0374EZJ8CU

Systematic Names

  • 2,2'-(Cyclohexylidenebis(p-phenyleneoxy))bis(2-methylbutyric acid)
  • Butanoic acid, 2,2'-(cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methyl-
  • Butyric acid, 2,2'-cyclohexane-1,1-diylbis(p-phenyleneoxy)bis-(2-methyl-

Registry Numbers

CAS Registry Number

  • 30299-08-2

FDA UNII

  • 0374EZJ8CU

System Generated Number

  • 0030299082

Structure Descriptors

InChI

1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)

InChIKey

BMOVQUBVGICXQN-UHFFFAOYSA-N

Smiles

C([C@@](Oc1ccc(C2(c3ccc(O[C@@](CC)(C)C(O)=O)cc3)CCCCC2)cc1)(C)C(O)=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 230mg/kg (230mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1553, 1981.
mouse LD50 intravenous 150mg/kg (150mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
mouse LD50 oral 1600mg/kg (1600mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
mouse LD50 subcutaneous 350mg/kg (350mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
rat LD50 intraperitoneal 205mg/kg (205mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981.
rat LD50 intravenous > 150mg/kg (150mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.
rat LD50 subcutaneous 1930mg/kg (1930mg/kg)   Drugs in Japan Vol. 6, Pg. 219, 1982.