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Substance Name: Cyclobenzaprine [INN]
RN: 303-53-7
UNII: 69O5WQQ5TI
InChIKey: JURKNVYFZMSNLP-UHFFFAOYSA-N

Note

  • Lisseril is synonymous for HCl.

Molecular Formula

  • C20-H21-N

Molecular Weight

  • 275.3929
 

Classification Codes

  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Muscle Relaxants, Central
  • Mutation Data
  • Neuromuscular Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Cyclobenzaprine
  • Cyclobenzaprine [INN]

Synonyms

  • 10,11-Dehydroamitriptyline
  • 5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene
  • 5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene [Italian]
  • 9715 R.P.
  • Ciclobenzaprina
  • Ciclobenzaprina [INN-Spanish]
  • Cyclobenzaprine
  • Cyclobenzaprinum
  • Cyclobenzaprinum [INN-Latin]
  • EINECS 206-145-8
  • Fexmid
  • HSDB 8305
  • Lisseril
  • MK 130
  • N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine
  • Proeptatriene
  • Proeptatriene [Italian]
  • Proheptatrien
  • Proheptatriene
  • Ro 4-1577
  • UNII-69O5WQQ5TI

Systematic Names

  • 1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-
  • 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, N,N-dimethyl-
  • Cyclobenzaprine
  • N,N-Dimethyl-3-(dibenzo(a,d)cycloheptene-4-ylidene)propylamine

Registry Numbers

CAS Registry Number

  • 303-53-7

FDA UNII

  • 69O5WQQ5TI

Related Registry Number

  • 6202-23-9 (hydrochloride)

System Generated Number

  • 0000303537

Structure Descriptors

InChI

InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3

InChIKey

JURKNVYFZMSNLP-UHFFFAOYSA-N

Smiles

CN(C)CCC=C1c2ccccc2C=Cc3ccccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 90mg/kg (90mg/kg)   Journal of Medicinal Chemistry. Vol. 6, Pg. 338, 1963.
mouse LD50 intravenous 36mg/kg (36mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 oral 250mg/kg (250mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.790 (none)   EST
Atmospheric OH Rate Constant 1.95E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.