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Substance Name: Prothipendyl [INN:BAN]
RN: 303-69-5
UNII: 5O6VWA87VA
InChIKey: JTTAUPUMOLRVRA-UHFFFAOYSA-N

Note

  • A neuroleptic azaphenothiazine.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H19-N3-S

Molecular Weight

  • 285.4131
 
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Names and Synonyms

Results Name

  • Prothipendyl [INN:BAN]

Name of Substance

  • Prothipendyl
  • Prothipendyl [INN:BAN]

Synonyms

  • 10-(3-Dimethylaminopropyl)-1-azaphenothiazin
  • 10-(3-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazin
  • 10H-Pyrido(3,2-b)(1,4)benzothiazine-10-propanamine, N,N-dimethyl-
  • 4-27-00-07169 (Beilstein Handbook Reference)
  • AY 56031
  • BRN 0259865
  • D 206
  • Dimethylamino-n-propyl-thiophenylpyridylamine
  • Dominal
  • EC 608-469-9
  • Largophren
  • LG 206
  • MH 05101
  • Prothipendyl
  • Prothipendylum
  • Prothipendylum [INN-Latin]
  • Protipendilo
  • Protipendilo [INN-Spanish]
  • Timoval
  • Timovan
  • Tolnate
  • Tumovan
  • UNII-5O6VWA87VA

Systematic Names

  • 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-
  • Prothipendyl

Registry Numbers

CAS Registry Number

  • 303-69-5

FDA UNII

  • 5O6VWA87VA

Related Registry Number

  • 1225-65-6 (hydrochloride)

System Generated Number

  • 0000303695

Structure Descriptors

InChI

1S/C16H19N3S/c1-18(2)11-6-12-19-13-7-3-4-8-14(13)20-15-9-5-10-17-16(15)19/h3-5,7-10H,6,11-12H2,1-2H3

InChIKey

JTTAUPUMOLRVRA-UHFFFAOYSA-N

Smiles

CN(C)CCCN1c2ccccc2Sc3cccnc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 135mg/kg (135mg/kg)   Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse LD50 oral 415mg/kg (415mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 489, 1958.
mouse LD50 subcutaneous 102mg/kg (102mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 374, 1964.
rat LD50 intravenous 25mg/kg (25mg/kg)   Therapie. Vol. 18, Pg. 373, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 4.010 (none)   EST
Atmospheric OH Rate Constant 1.98E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.