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Substance Name: Hydralazine hydrochloride [USP:JAN]
RN: 304-20-1
UNII: FD171B778Y
InChIKey: GRRXUTATUJXPLW-UHFFFAOYSA-N

Note

  • A direct-acting vasodilator that is used as an antihypertensive agent.

Molecular Formula

  • C8-H8-N4.Cl-H

Molecular Weight

  • 195.652
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Hydralazine hydrochloride [USP:JAN]

Synonyms

  • 1(2H)-Phthalazinone, hydrazone, hydrochloride
  • 1(2H)-Phthalazinone, hydrazone, monohydrochloride
  • 1-Hydrazinophthalazine hydrochloride
  • 1-Hydrazinophthalazine monohydrochloride
  • Aiselazine
  • Apresine
  • Apresoline
  • Apresoline hydrochloride
  • Apresoline-esidrix
  • CCRIS 334
  • Dralzine
  • EINECS 206-151-0
  • HSDB 434
  • Hydralazine chloride
  • Hydralazine HCl
  • Hydralazine hydrochloride
  • Hydralazine monohydrochloride
  • Hyperazin
  • Hyperex
  • Lopress
  • Nor-press 25
  • NSC 89394
  • Phthalazinone, hydrazone, monohydrochloride
  • Praparat 5968
  • Rolazine
  • Slow-Apresolin
  • UNII-FD171B778Y

Systematic Names

  • 1(2H)-Phthalazinone, hydrazone, monohydrochloride
  • Hydralazine hydrochloride
  • Phthalazine, 1-hydrazino-, monohydrochloride
  • Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)

Superlist Name

  • Hydralazine hydrochloride

Mixture Names

  • Apresazide
  • Bidil
  • H.H. 25/25
  • H.H. 50/50
  • PRA 027
  • Ser-Ap-Es
  • Unipres

Registry Numbers

CAS Registry Number

  • 304-20-1

FDA UNII

  • FD171B778Y

Other Registry Numbers

  • 1202866-95-2
  • 40671-54-3

Related Registry Number

  • 86-54-4 (Parent)

System Generated Number

  • 0000304201

Molecular Formulas

Molecular Formula

  • C8-H8-N4.Cl-H

Molecular Formula Fragments

  • C8-H8-N4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C9H9N3.ClH/c1-10-9-8-5-3-2-4-7(8)6-11-12-9;/h2-6H,1H3,(H,10,12);1H

InChIKey

GRRXUTATUJXPLW-UHFFFAOYSA-N

Smiles

Cl.C\N=C/1\NN=Cc2ccccc12

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 83mg/kg (83mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 368, 1951.
mouse LD50 intravenous 71mg/kg (71mg/kg)   Drugs in Japan Vol. -, Pg. 1006, 1995.
mouse LD50 oral 188mg/kg (188mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969.
mouse LD50 subcutaneous 73mg/kg (73mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 6, Pg. 362, 1954.
rat LD50 intravenous 34mg/kg (34mg/kg)   Drugs in Japan Vol. 6, Pg. 619, 1982.
rat LD50 oral 280mg/kg (280mg/kg)   Drugs in Japan Vol. -, Pg. 1006, 1995.