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Substance Name: Hydralazine hydrochloride [USP:JAN]
RN: 304-20-1
UNII: FD171B778Y
InChIKey: ZUXNZUWOTSUBMN-UHFFFAOYSA-N
Note
- A direct-acting vasodilator that is used as an antihypertensive agent.
Molecular Formula
- C8-H8-N4.Cl-H
Molecular Weight
- 196.6369
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antihypertensive
- Antihypertensive Agents
- Drug / Therapeutic Agent
- Mutation Data
- Reproductive Effect
- Tumor Data
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Hydralazine hydrochloride [USP:JAN]
Synonyms
- 1(2H)-Phthalazinone, hydrazone, hydrochloride
- 1(2H)-Phthalazinone, hydrazone, monohydrochloride
- 1-Hydrazinophthalazine hydrochloride
- 1-Hydrazinophthalazine monohydrochloride
- Aiselazine
- Apresine
- Apresoline
- Apresoline hydrochloride
- Apresoline-esidrix
- CCRIS 334
- Dralzine
- EINECS 206-151-0
- HSDB 434
- Hydralazine chloride
- Hydralazine HCl
- Hydralazine hydrochloride
- Hydralazine monohydrochloride
- Hyperazin
- Hyperex
- Lopress
- Nor-press 25
- NSC 89394
- Phthalazinone, hydrazone, monohydrochloride
- Praparat 5968
- Rolazine
- Slow-Apresolin
- UNII-FD171B778Y
Systematic Names
- 1(2H)-Phthalazinone, hydrazone, monohydrochloride
- Hydralazine hydrochloride
- Phthalazine, 1-hydrazino-, monohydrochloride
- Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
Superlist Name
- Hydralazine hydrochloride
Mixture Names
- Apresazide
- Bidil
- H.H. 25/25
- H.H. 50/50
- PRA 027
- Ser-Ap-Es
- Unipres
Registry Numbers
CAS Registry Number
- 304-20-1
FDA UNII
- FD171B778Y
Other Registry Numbers
- 1202866-95-2
- 40671-54-3
Related Registry Number
- 86-54-4 (Parent)
System Generated Number
- 0000304201
Molecular Formulas
Molecular Formula
- C8-H8-N4.Cl-H
Molecular Formula Fragments
- C8-H8-N4
- Cl-H
- COMPONENT
Structure Descriptors
InChI
1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1HInChIKey
ZUXNZUWOTSUBMN-UHFFFAOYSA-NSmiles
Cl.NNc1nncc2ccccc12Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 83mg/kg (83mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 368, 1951. | |
| mouse | LD50 | intravenous | 71mg/kg (71mg/kg) | Drugs in Japan Vol. -, Pg. 1006, 1995. | |
| mouse | LD50 | oral | 188mg/kg (188mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969. | |
| mouse | LD50 | subcutaneous | 73mg/kg (73mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 6, Pg. 362, 1954. |
| rat | LD50 | intravenous | 34mg/kg (34mg/kg) | Drugs in Japan Vol. 6, Pg. 619, 1982. | |
| rat | LD50 | oral | 280mg/kg (280mg/kg) | Drugs in Japan Vol. -, Pg. 1006, 1995. |