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Substance Name: Succimer [USAN:INN:BAN]
RN: 304-55-2
UNII: DX1U2629QE
InChIKey: ACTRVOBWPAIOHC-XIXRPRMCSA-N

Note

  • A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.

Molecular Formula

  • C4-H6-O4-S2

Molecular Weight

  • 182.2194
 

Classification Codes

  • Antidotes
  • Chelating Agents
  • Diagnostic Aid
  • Drug / Therapeutic Agent
  • Protective Agents
  • Reproductive Effect
  • Sequestering Agents
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Names and Synonyms

Name of Substance

  • Succimer
  • Succimer [USAN:INN:BAN]

MeSH Heading

  • Succimer

Synonyms

  • (R*,S*)-2,3-Dimercaptobutanedioic acid
  • 3-03-00-01033 (Beilstein Handbook Reference)
  • BRN 1725150
  • Chemet
  • DIM-SA
  • DMS
  • DMSA
  • EINECS 206-155-2
  • HSDB 6783
  • meso-2,3-Dimercaptosuccinic acid
  • meso-Dimercaptosuccinic acid
  • Ro 1-7977
  • Succimer
  • Succimero
  • Succimero [INN-Spanish]
  • Succimerum
  • Succimerum [INN-Latin]
  • UNII-DX1U2629QE

Systematic Names

  • Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel-
  • Butanedioic acid, 2,3-dimercapto-, (R*,S*)-
  • Succimer
  • Succinic acid, 2,3-dimercapto-, meso-

Registry Numbers

CAS Registry Number

  • 304-55-2

FDA UNII

  • DX1U2629QE

Related Registry Number

  • 2418-14-6 (parent cpd)

System Generated Number

  • 0000304552

Structure Descriptors

InChI

1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+

InChIKey

ACTRVOBWPAIOHC-XIXRPRMCSA-N

Smiles

[C@H]([C@H](C(=O)O)S)(C(=O)O)S

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   National Technical Information Service. Vol. AD691-490,
mouse LD50 oral > 5011mg/kg (5011mg/kg)   CRC Critical Reviews in Toxicology. Vol. 20, Pg. 83, 1989.
mouse LD50 subcutaneous 1725mg/kg (1725mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 283, 1961.
rabbit LDLo intravenous 2700mg/kg (2700mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 283, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 193 deg C   EXP
log P (octanol-water) -1.010 (none)   EST
Atmospheric OH Rate Constant 9.40E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.