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Substance Name: Geldanamycin
RN: 30562-34-6
UNII: Z3K3VJ16KU
InChIKey: QTQAWLPCGQOSGP-KSRBKZBZSA-N
Note
- From culture filtrates of Streptomyces hygroscopicus var. geldanus var. Nova.
Molecular Formula
- C29-H40-N2-O9
Molecular Weight
- 560.64
Classification Codes
- Anti-Infective Agents
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Antiviral Agents
- Cysteine Proteinase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Mutation Data
- Natural Product
- Protease Inhibitors
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Names and Synonyms
Name of Substance
- Geldanamycin
Synonyms
- BRN 1633093
- Geldanamycin
- NSC 122750
- U 29135
- U-29135
- UNII-Z3K3VJ16KU
Systematic Name
- Geldanamycin
Registry Numbers
CAS Registry Number
- 30562-34-6
FDA UNII
- Z3K3VJ16KU
System Generated Number
- 0030562346
Structure Descriptors
InChI
InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1InChIKey
QTQAWLPCGQOSGP-KSRBKZBZSA-NSmiles
CO[C@H]1C[C@H](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD | intravenous | > 4200ug/kg (4.2mg/kg) | Cancer Chemotherapy and Pharmacology. Vol. 36, Pg. 305, 1995. | |
mouse | LD | intravenous | > 50mg/kg (50mg/kg) | Cancer Chemotherapy and Pharmacology. Vol. 36, Pg. 305, 1995. | |
mouse | LD50 | intraperitoneal | 1mg/kg (1mg/kg) | "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971. | |
rat | LD50 | oral | 2500mg/kg (2500mg/kg) | Journal of Antibiotics. Vol. 23, Pg. 442, 1970. |