Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Geldanamycin
RN: 30562-34-6
UNII: Z3K3VJ16KU
InChIKey: QTQAWLPCGQOSGP-KSRBKZBZSA-N

Note

  • Unlike the related ansamycins, geldanamycin possesses a methoxyl at C17 on the quinone; from culture filtrates of Streptomyces hygroscopicus var. geldanus var. Nova.

Molecular Formula

  • C29-H40-N2-O9

Molecular Weight

  • 560.64
 

Classification Codes

  • Anti-Infective Agents
  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Antiviral Agents
  • Cysteine Proteinase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Mutation Data
  • Natural Product
  • Protease Inhibitors
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Geldanamycin

Synonyms

  • BRN 1633093
  • Geldanamycin
  • NSC 122750
  • U 29135
  • U-29135
  • UNII-Z3K3VJ16KU

Systematic Name

  • Geldanamycin

Registry Numbers

CAS Registry Number

  • 30562-34-6

FDA UNII

  • Z3K3VJ16KU

System Generated Number

  • 0030562346

Structure Descriptors

InChI

1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

InChIKey

QTQAWLPCGQOSGP-KSRBKZBZSA-N

Smiles

CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(=C\C=C/[C@H](OC)[C@@H](OC(=O)N)\C(=C\[C@H](C)[C@H]1O)\C)\C)C2=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 4200ug/kg (4.2mg/kg)   Cancer Chemotherapy and Pharmacology. Vol. 36, Pg. 305, 1995.
mouse LD intravenous > 50mg/kg (50mg/kg)   Cancer Chemotherapy and Pharmacology. Vol. 36, Pg. 305, 1995.
mouse LD50 intraperitoneal 1mg/kg (1mg/kg)   "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971.
rat LD50 oral 2500mg/kg (2500mg/kg)   Journal of Antibiotics. Vol. 23, Pg. 442, 1970.