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Substance Name: Deferiprone [USAN:INN:BAN]
RN: 30652-11-0
UNII: 2BTY8KH53L
InChIKey: TZXKOCQBRNJULO-UHFFFAOYSA-N

Classification Codes

  • Chelating Agents
  • Iron Chelating Agents
  • Sequestering Agents
  • Treatment of Iron Overload in Patients with Excessive Body Iron Stores

Molecular Formula

  • C7-H9-N-O2

Molecular Weight

  • 139.1531
 

Names and Synonyms

Name of Substance

  • Deferiprone
  • Deferiprone [USAN:INN:BAN]

Synonyms

  • 1,2-Dimethyl-3-hydroxy-4(1H)-pyridinone
  • 1,2-Dimethyl-3-hydroxypyrid-4-one
  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
  • 5-21-12-00114 (Beilstein Handbook Reference)
  • APO-066
  • APO-66
  • BRN 1447108
  • CCRIS 8318
  • CP20
  • CP20 (Chelating agent)
  • Deferiprone
  • DN-180-01-AF
  • Ferriprox
  • HSDB 8335
  • L1
  • PL1
  • UNII-2BTY8KH53L

Systematic Names

  • 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
  • 4(1H)-Pyridinone, 1,2-dimethyl-3-hydroxy-
  • 4(1H)-Pyridone, 3-hydroxy-1,2-dimethyl- (8CI)

Registry Numbers

CAS Registry Number

  • 30652-11-0

FDA UNII

  • 2BTY8KH53L

System Generated Number

  • 0030652110

Structure Descriptors

InChI

1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

InChIKey

TZXKOCQBRNJULO-UHFFFAOYSA-N

Smiles

CN1C=CC(=O)C(=C1C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo oral 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: FOOD INTAKE (ANIMAL)
BioMetals. Vol. 10, Pg. 247, 1997.
mammal (species unspecified) LD50 unreported > 1gm/kg (1000mg/kg)   Archives of Toxicology, Supplement. Vol. 18, Pg. 202, 1996.
mouse LD50 intraperitoneal 983mg/kg (983mg/kg)   Blood. Vol. 76, Pg. 2389, 1990.
rat LD50 intraperitoneal 600mg/kg (600mg/kg)   Drugs of the Future. Vol. 13, Pg. 413, 1988.
rat LD50 oral 2gm/kg (2000mg/kg) CARDIAC: OTHER CHANGES Archives of Toxicology, Supplement. Vol. 18, Pg. 202, 1996.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.77 (none)   EXP
Atmospheric OH Rate Constant 9.74E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.