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Substance Name: Hexamethylene bisacetamide
RN: 3073-59-4
UNII: LA133J59VU
InChIKey: BNQSTAOJRULKNX-UHFFFAOYSA-N

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Hematinics
  • Hematologic Agents
  • Human Data

Molecular Formula

  • C10-H20-N2-O2

Molecular Weight

  • 200.28
 
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Names and Synonyms

Name of Substance

  • Hexamethylene bisacetamide

Synonyms

  • 4-04-00-01331 (Beilstein Handbook Reference)
  • BRN 1775764
  • CCRIS 7677
  • Diacetyldiaminohexane
  • Hexamethylene bisacetamide
  • Hexamethylenebisacetamide
  • Hexamethylenediacetamide
  • HMBA
  • N,N'-1,6-Hexanediylbisacetamide
  • N,N'-Diacetylhexamethylenediamine
  • N,N'-Hexamethylenebisacetamide
  • NSC 95580
  • NSC-95580
  • UNII-LA133J59VU

Systematic Names

  • Acetamide, N,N'-1,6-hexanediylbis- (9CI)
  • Acetamide, N,N'-hexamethylenebis-
  • Hexamethylene bisacetamide

Registry Numbers

CAS Registry Number

  • 3073-59-4

FDA UNII

  • LA133J59VU

System Generated Number

  • 0003073594

Structure Descriptors

InChI

1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)

InChIKey

BNQSTAOJRULKNX-UHFFFAOYSA-N

Smiles

C(=O)(NCCCCCCNC(=O)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intravenous 4270mg/kg/10D (4270mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: THROMBOCYTOPENIA
Cancer Research. Vol. 47, Pg. 5788, 1987.
mouse LD50 intraperitoneal 4100mg/kg (4100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983-Vol. 3, Pg. 263, 1985.
rat LD50 intraperitoneal 3250mg/kg (3250mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983-Vol. 3, Pg. 263, 1985.