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Substance Name: Troxipide [INN:JAN]
RN: 30751-05-4
UNII: W6QJX1Q00Z
InChIKey: YSIITVVESCNIPR-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C15-H22-N2-O4

Molecular Weight

  • 294.349
 
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Names and Synonyms

Name of Substance

  • Troxipide
  • Troxipide [INN:JAN]

Synonyms

  • 3,4,5-Trimethoxy-N-(3-piperidyl)benzamide
  • 3-(3,4,5-Trimethoxybenzamido)piperidine
  • 5-22-08-00030 (Beilstein Handbook Reference)
  • Benzamide, 3,4,5-trimethoxy-N-3-piperidinyl-
  • BRN 0493078
  • KU-54
  • Troxipida
  • Troxipida [Spanish]
  • Troxipide
  • Troxipidum
  • Troxipidum [Latin]
  • UNII-W6QJX1Q00Z

Systematic Names

  • (+-)-3,4,5-Trimethoxy-N-3-piperidylbenzamide
  • Benzamide, N-(3-piperidyl)-3,4,5-trimethoxy-

Registry Numbers

CAS Registry Number

  • 30751-05-4

FDA UNII

  • W6QJX1Q00Z

System Generated Number

  • 0030751054

Structure Descriptors

InChI

1S/C15H22N2O4/c1-19-12-7-10(8-13(20-2)14(12)21-3)15(18)17-11-5-4-6-16-9-11/h7-8,11,16H,4-6,9H2,1-3H3,(H,17,18)

InChIKey

YSIITVVESCNIPR-UHFFFAOYSA-N

Smiles

C(c1cc(c(c(c1)OC)OC)OC)(=O)N[C@@H]1CNCCC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 690mg/kg (690mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 3422, 1978.
mouse LD50 intraperitoneal 300mg/kg (300mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 3422, 1978.
mouse LD50 intravenous 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 3422, 1978.
mouse LD50 oral 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 485, 1980.
mouse LD50 subcutaneous 1550mg/kg (1550mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 3422, 1978.
mouse LD50 subcutaneous 1550mg/kg (1550mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 3422, 1978.
rat LD50 intraperitoneal 340mg/kg (340mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 3422, 1978.
rat LD50 oral 2100mg/kg (2100mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 485, 1980.
rat LD50 oral 2100mg/kg (2100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 485, 1980.
rat LD50 subcutaneous 4150mg/kg (4150mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 485, 1980.