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Substance Name: Doxapram [INN:BAN]
RN: 309-29-5
UNII: 94F3830Q73
InChIKey: XFDJYSQDBULQSI-UHFFFAOYSA-N

Note

  • A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

Molecular Formula

  • C24-H30-N2-O2

Molecular Weight

  • 378.513
 

Classification Codes

  • Central Nervous System Agents
  • Central Nervous System Stimulants
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Respiratory System Agents
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Names and Synonyms

Name of Substance

  • Doxapram
  • Doxapram [INN:BAN]
  • Doxapram [USP:JAN]

MeSH Heading

  • Doxapram

Synonyms

  • 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
  • 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-
  • 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-
  • BRN 0628691
  • Doxapram
  • Doxapramum
  • Doxapramum [INN-Latin]
  • EINECS 206-216-3
  • HSDB 3318
  • UNII-94F3830Q73

Systematic Names

  • 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl- (9CI)
  • 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-
  • Doxapram

Registry Numbers

CAS Registry Number

  • 309-29-5

FDA UNII

  • 94F3830Q73

System Generated Number

  • 0000309295

Structure Descriptors

InChI

1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3

InChIKey

XFDJYSQDBULQSI-UHFFFAOYSA-N

Smiles

CCN1CC(C(C1=O)(c2ccccc2)c3ccccc3)CCN4CCOCC4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 268mg/kg (268mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacy and Pharmacology. Vol. 30, Pg. 522, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.420 (none)   EST
Atmospheric OH Rate Constant 1.91E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.