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Substance Name: Methohexital sodium [USP]
RN: 309-36-4
UNII: 60200PNZ7Q
InChIKey: KDXZREBVGAGZHS-UHFFFAOYSA-M

Note

  • An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.

Molecular Formula

  • C14-H18-N2-O3.Na

Molecular Weight

  • 284.289
 

Classification Codes

  • Anesthetic (Intravenous)
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Methohexital sodium [USP]

Synonyms

  • 1-Methyl-5-allyl-5-(1-methyl-2-pentynyl)barbituric acid sodium salt
  • 5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid sodium salt
  • Barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, sodium deriv.
  • Brevimytal
  • Brevital
  • Brevital sodium
  • Brietal
  • Brietal sodique
  • Brietal sodium
  • CCRIS 4716
  • EINECS 206-217-9
  • Enallynymal sodium
  • Lilly 22451
  • Methohexital sodium
  • Methohexitone sodium
  • Sodium 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbiturate
  • Sodium methohexital
  • Sodium methohexitone
  • Sodium-dl-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbiturate
  • UNII-60200PNZ7Q

Systematic Names

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, (+-)-, monosodium salt
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, sodium salt
  • Barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-, sodium salt
  • Methohexital sodium
  • Sodium methohexital

Superlist Names

  • Brevital
  • DEA No. 2264
  • Methohexital

Registry Numbers

CAS Registry Number

  • 309-36-4

FDA UNII

  • 60200PNZ7Q

Other Registry Numbers

  • 22151-68-4
  • 32671-83-3
  • 33975-80-3
  • 60634-69-7

System Generated Number

  • 0000309364

Molecular Formulas

Molecular Formula

  • C14-H18-N2-O3.Na

Molecular Formula Fragments

  • C14-H18-N2-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C14H18N2O3.Na/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18;/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19);/q;+1/p-1

InChIKey

KDXZREBVGAGZHS-UHFFFAOYSA-M

Smiles

C1([C@@](C(N=C(N1C)[O-])=O)([C@@H](C#CCC)C)CC=C)=O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 implant 25mg/kg (25mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 75, 1969.
dog LD50 intravenous 21500ug/kg (21.5mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 89, Pg. 292, 1955.
mouse LD50 intravenous 35600ug/kg (35.6mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 247, 1976.
rabbit LD50 implant 10mg/kg (10mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 75, 1969.
rabbit LD50 intravenous 8640ug/kg (8.64mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 89, Pg. 292, 1955.
rat LD50 implant 33mg/kg (33mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 75, 1969.
rat LD50 intravenous 24890ug/kg (24.89mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 89, Pg. 292, 1955.
women TDLo intravenous 25ug/kg (0.025mg/kg) GASTROINTESTINAL: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
Journal of Oral Surgery. Vol. 30, Pg. 906, 1972.