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Substance Name: Halcinonide [USAN:USP:INN:BAN:JAN]
RN: 3093-35-4
UNII: SI86V6QNEG
InChIKey: MUQNGPZZQDCDFT-JNQJZLCISA-N
Note
- A glucocorticoid used topically in the treatment of DERMATITIS; ECZEMA; or PSORIASIS. It may cause skin irritation.
Molecular Formula
- C24-H32-Cl-F-O5
Molecular Weight
- 454.9628
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Inflammatory (Topical)
- Anti-Inflammatory Agents
- Drug / Therapeutic Agent
- Mutation Data
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Names and Synonyms
Name of Substance
- Halcinonide
- Halcinonide [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Halcinonide
Synonyms
- 21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal with acetone
- 5-19-06-00301 (Beilstein Handbook Reference)
- Ascochrom
- Betacorton
- BRN 1358242
- EINECS 221-439-6
- Halciderm
- Halcimat
- Halcinonida
- Halcinonida [INN-Spanish]
- Halcinonide
- Halcinonidum
- Halcinonidum [INN-Latin]
- Halcort
- Halog
- Halog-E
- Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-
- SQ 18566
- SQ-18,566
- UNII-SI86V6QNEG
- Volog
Systematic Names
- Halcinonide
- Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-, cyclic16,17-acetal with acetone
- Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-
Registry Numbers
CAS Registry Number
- 3093-35-4
FDA UNII
- SI86V6QNEG
System Generated Number
- 0003093354
Structure Descriptors
InChI
InChI=1S/C24H32ClFO5/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,26)17(28)11-22(16,4)24(19,31-20)18(29)12-25/h9,15-17,19,28H,5-8,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1InChIKey
MUQNGPZZQDCDFT-JNQJZLCISA-NSmiles
CC1(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 215, 1977. | |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-15, 1982. | |
mouse | LD50 | subcutaneous | 409mg/kg (409mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982. | |
rat | LD50 | intraperitoneal | 39800ug/kg (39.8mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982. | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 5, Pg. APP-15, 1982. | |
rat | LD50 | subcutaneous | 95500ug/kg (95.5mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 264 dec | deg C | EXP | |
log P (octanol-water) | 2.930 | (none) | EST | |
Atmospheric OH Rate Constant | 1.27E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.