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Substance Name: Halcinonide [USAN:USP:INN:BAN:JAN]
RN: 3093-35-4
UNII: SI86V6QNEG
InChIKey: MUQNGPZZQDCDFT-JNQJZLCISA-N

Note

  • A glucocorticoid used topically in the treatment of DERMATITIS; ECZEMA; or PSORIASIS. It may cause skin irritation.

Molecular Formula

  • C24-H32-Cl-F-O5

Molecular Weight

  • 454.9628
 

Classification Codes

  • Anti-Inflammatory (Topical)
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Halcinonide
  • Halcinonide [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Halcinonide

Synonyms

  • 21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal with acetone
  • 5-19-06-00301 (Beilstein Handbook Reference)
  • Ascochrom
  • Betacorton
  • BRN 1358242
  • EINECS 221-439-6
  • Halciderm
  • Halcimat
  • Halcinonida
  • Halcinonida [INN-Spanish]
  • Halcinonide
  • Halcinonidum
  • Halcinonidum [INN-Latin]
  • Halcort
  • Halog
  • Halog-E
  • Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-
  • SQ 18566
  • SQ-18,566
  • UNII-SI86V6QNEG
  • Volog

Systematic Names

  • Halcinonide
  • Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-, cyclic16,17-acetal with acetone
  • Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 3093-35-4

FDA UNII

  • SI86V6QNEG

System Generated Number

  • 0003093354

Structure Descriptors

InChI

1S/C24H32ClFO5/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,26)17(28)11-22(16,4)24(19,31-20)18(29)12-25/h9,15-17,19,28H,5-8,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChIKey

MUQNGPZZQDCDFT-JNQJZLCISA-N

Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3C[C@@H]5[C@]4(OC(O5)(C)C)C(=O)CCl)C)O)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 215, 1977.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
mouse LD50 subcutaneous 409mg/kg (409mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 intraperitoneal 39800ug/kg (39.8mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 5, Pg. APP-15, 1982.
rat LD50 subcutaneous 95500ug/kg (95.5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 264 dec deg C   EXP
log P (octanol-water) 2.930 (none)   EST
Atmospheric OH Rate Constant 1.27E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.