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Substance Name: Doxifluridine [INN:JAN]
RN: 3094-09-5
UNII: V1JK16Y2JP
InChIKey: ZWAOHEXOSAUJHY-ZIYNGMLESA-N

Molecular Formula

  • C9-H11-F-N2-O5

Molecular Weight

  • 246.193
 

Classification Codes

  • Antimetabolites
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Appetite Stimulants
  • Central Nervous System Agents
  • Central Nervous System Stimulants
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Immunosuppressive Agents
  • Mutation Data
  • Noxae
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Doxifluridine
  • Doxifluridine [INN:JAN]

Synonyms

  • 1-(beta-D-5-Desoxyribofuranoxyl)-5-fluoruracil
  • 5'-Deoxy-5-fluorouridine
  • 5'-Dfur
  • 5'-Doxifluridine
  • Doxifluridina
  • Doxifluridina [INN-Spanish]
  • Doxifluridine
  • Doxifluridinum
  • Doxifluridinum [INN-Latin]
  • EINECS 221-440-1
  • Flutron
  • Furtulon
  • Ro 21-9738
  • Ro 219738
  • UNII-V1JK16Y2JP

Systematic Names

  • 5'-Deoxy-5-fluorouridine
  • Doxifluridine
  • Uridine, 5'-deoxy-5-fluoro-
  • Uridine-5'-deoxy-5-fluoro-

Registry Numbers

CAS Registry Number

  • 3094-09-5

FDA UNII

  • V1JK16Y2JP

System Generated Number

  • 0003094095

Structure Descriptors

InChI

1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1

InChIKey

ZWAOHEXOSAUJHY-ZIYNGMLESA-N

Smiles

n1([C@H]2[C@@H]([C@H](O)[C@H](O2)C)O)c([nH]c(=O)c(c1)F)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous > 1gm/kg (1000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
mouse LDLo oral 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 intravenous > 1gm/kg (1000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 oral 3390mg/kg (3390mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 13(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 190 deg C   EXP
pKa Dissociation Constant 7.4 (none)   EXP
log P (octanol-water) -1.400 (none)   EST
Atmospheric OH Rate Constant 6.69E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.