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Substance Name: Lofexidine [INN:BAN]
RN: 31036-80-3
UNII: UI82K0T627
InChIKey: KSMAGQUYOIHWFS-UHFFFAOYSA-N

Note

  • Reduces narcotic withdrawal symptoms.

Molecular Formula

  • C11-H12-Cl2-N2-O

Molecular Weight

  • 259.1348
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-2 Receptor Agonists
  • Adrenergic alpha-Agonists
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Narcotic Antagonists
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Lofexidine
  • Lofexidine [INN:BAN]

Synonyms

  • 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole
  • 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline
  • Lofexidina
  • Lofexidina [INN-Spanish]
  • Lofexidine
  • Lofexidinum
  • Lofexidinum [INN-Latin]
  • UNII-UI82K0T627

Systematic Names

  • 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro- (9CI)
  • 2-Imidazoline 2-(1-(2,6-dichlorophenoxy)ethyl)-

Registry Numbers

CAS Registry Number

  • 31036-80-3

FDA UNII

  • UI82K0T627

Related Registry Number

  • 21498-08-8 (mono-hydrochloride)

System Generated Number

  • 0031036803

Structure Descriptors

InChI

1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)

InChIKey

KSMAGQUYOIHWFS-UHFFFAOYSA-N

Smiles

c1(c(cccc1Cl)Cl)O[C@@H](C=1NCCN1)C

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 127 deg C   EXP
log P (octanol-water) 3.580 (none)   EST
Atmospheric OH Rate Constant 8.71E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.