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Substance Name: Paraoxon
RN: 311-45-5
UNII: Q9CX8P80JW
InChIKey: WYMSBXTXOHUIGT-UHFFFAOYSA-N
Note
- An organophosphate cholinesterase inhibitor that is used as a pesticide.
Molecular Formula
- C10-H14-N-O6-P
Molecular Weight
- 275.1956
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Agricultural Chemical
- Cholinergic Agents
- Cholinesterase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Insecticide
- Insecticides
- Mutation Data
- Neurotransmitter Agents
- Pesticides
Superlist Classification Code
- Reportable Quantity (RQ) = 100 lb
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Ethyl paraoxon
- Paraoxon
MeSH Heading
- Paraoxon
Synonyms
- 4-06-00-01327 (Beilstein Handbook Reference)
- AI3-16087
- BRN 1915526
- CCRIS 7780
- Chinorta
- Chinorto
- Diaethyl-p-nitrophenylphosphorsaeureester
- Diaethyl-p-nitrophenylphosphorsaeureester [German]
- Diethyl 4-nitrophenyl phosphate
- Diethyl p-nitrophenyl phosphate
- Diethyl paraoxon
- Diethyl-p-nitrofenyl ester kyseliny fosforecne
- Diethyl-p-nitrofenyl ester kyseliny fosforecne [Czech]
- Diethylparaoxon
- E 600
- E 600 (pesticide)
- E-600
- EINECS 206-221-0
- ENT 16,087
- Ester 25
- Ethyl p-nitrophenyl ethylphosphate
- Ethyl paraoxon
- Eticol
- Fosfakol
- HC 2072
- HSDB 6044
- Mintaco
- Mintacol
- Mintisal
- Miotisal
- Miotisal A
- NSC 404110
- O,O'Diaethyl-p-nitrophenylphosphat
- O,O'Diaethyl-p-nitrophenylphosphat [German]
- O,O-Diethyl O-p-nitrophenyl phosphate
- O,O-Diethyl phosphoric acid O-p-nitrophenyl ester
- O,O-Dietyl-O-p-nitrofenylfosfat
- O,O-Dietyl-O-p-nitrofenylfosfat [Czech]
- Oxyparathion
- p-Nitrophenyl diethyl phosphate
- p-Nitrophenyl diethylphosphate
- Paraoxon
- Paraoxone
- Paroxan
- Pestox 101
- Phenol, p-nitro-, ester with diethyl phosphate
- Phosphachole
- Phosphacol
- Phosphakol
- Phosphonothioic acid, diethylparanitrophenyl ester
- Phosphoric acid diethyl 4-nitrophenyl ester
- Phosphoric acid, diethyl p-nitrophenyl ester
- RCRA waste number P041
- Soluglacit
- Soluglaucit
- TS 219
- UNII-Q9CX8P80JW
Systematic Names
- Diethyl 4-nitrophenyl phosphate
- Paraoxon
- Phosphoric acid, diethyl 4-nitrophenyl ester
- Phosphoric acid, diethyl p-nitrophenyl ester
Superlist Names
- Diethyl-p-nitrophenyl phosphate
- Paraoxon
- Phosphoric acid, diethyl 4-nitrophenyl ester
- RCRA waste no. P041
Registry Numbers
CAS Registry Number
- 311-45-5
FDA UNII
- Q9CX8P80JW
System Generated Number
- 0000311455
Structure Descriptors
InChI
1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3InChIKey
WYMSBXTXOHUIGT-UHFFFAOYSA-NSmiles
P(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | subcutaneous | 700ug/kg (0.7mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953. |
chicken | LD50 | intramuscular | 175ug/kg (0.175mg/kg) | Journal of Toxicology and Environmental Health. Vol. 23, Pg. 103, 1988. | |
chicken | LD50 | intraperitoneal | 303ug/kg (0.303mg/kg) | Pesticide Biochemistry and Physiology. Vol. 26, Pg. 202, 1986. | |
chicken | LD50 | oral | 2mg/kg (2mg/kg) | Biochemical Pharmacology. Vol. 16, Pg. 1183, 1967. | |
frog | LD50 | intraperitoneal | 2587ug/kg (2.587mg/kg) | Pesticide Biochemistry and Physiology. Vol. 26, Pg. 202, 1986. | |
frog | LD50 | subcutaneous | 60mg/kg (60mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953. |
guinea pig | LD50 | subcutaneous | 500ug/kg (0.5mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953. |
man | TDLo | oral | 14mg/kg (14mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: COMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archiv fuer Toxikologie. Vol. 25, Pg. 329, 1969. |
mouse | LD50 | intramuscular | 710ug/kg (0.71mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 237, Pg. 211, 1959. | |
mouse | LD50 | intraperitoneal | 330ug/kg (0.33mg/kg) | Farmakologiya i Toksikologiya Vol. 35, Pg. 494, 1972. | |
mouse | LD50 | intravenous | 520ug/kg (0.52mg/kg) | Toxicology and Applied Pharmacology. Vol. 22, Pg. 684, 1972. | |
mouse | LD50 | oral | 760ug/kg (0.76mg/kg) | HHS Publication Vol. FDA-80-1076, Pg. 212, 1980. | |
mouse | LD50 | subcutaneous | 270ug/kg (0.27mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: TREMOR | Journal of Pharmacy and Pharmacology. Vol. 34, Pg. 603, 1982. |
mouse | LD50 | unreported | 560ug/kg (0.56mg/kg) | Pharmaceutical Chemistry Journal Vol. 3, Pg. 508, 1969. | |
mouse | LDLo | parenteral | 600ug/kg (0.6mg/kg) | Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 388, 1973. | |
rabbit | LD50 | intraperitoneal | 3310ug/kg (3.31mg/kg) | Archives Belges de Medecine Sociale, Hygiene, Medecine du Trevail et Medecine Legale. Vol. (Suppl), Pg. 226, 1984. | |
rabbit | LD50 | intravenous | 300ug/kg (0.3mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953. |
rabbit | LD50 | skin | 5mg/kg (5mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953. |
rabbit | LD50 | subcutaneous | 230ug/kg (0.23mg/kg) | Drugs in Japan Vol. 6, Pg. 113, 1982. | |
rabbit | LD50 | unreported | 300ug/kg (0.3mg/kg) | American Journal of Ophthalmology. Vol. 53, Pg. 512, 1962. | |
rat | LD50 | intramuscular | 446ug/kg (0.446mg/kg) | British Journal of Industrial Medicine. Vol. 22, Pg. 317, 1965. | |
rat | LD50 | intraperitoneal | 716ug/kg (0.716mg/kg) | Pesticide Biochemistry and Physiology. Vol. 26, Pg. 202, 1986. | |
rat | LD50 | intravenous | 240ug/kg (0.24mg/kg) | Canadian Journal of Biochemistry and Physiology. Vol. 34, Pg. 197, 1956. | |
rat | LD50 | oral | 1800ug/kg (1.8mg/kg) | Biochemical Pharmacology. Vol. 16, Pg. 1183, 1967. | |
rat | LD50 | subcutaneous | 426ug/kg (0.426mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1983, 1977. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 300 | deg C | EXP | |
log P (octanol-water) | 1.98 | (none) | EXP | |
Water Solubility | 3640 | mg/L | 20 | EXP |
Vapor Pressure | 1.10E-06 | mm Hg | 25 | EXP |
Henry's Law Constant | 1.09E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.91E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.