Skip Navigation
ChemIDplus A TOXNET DATABASE Lite•Browse•Advanced

Substance Name: Paraoxon
RN: 311-45-5
UNII: Q9CX8P80JW
InChIKey: WYMSBXTXOHUIGT-UHFFFAOYSA-N

Note

  • An organophosphate cholinesterase inhibitor that is used as a pesticide.

Molecular Formula

  • C10-H14-N-O6-P

Molecular Weight

  • 275.1956
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Insecticide
  • Insecticides
  • Mutation Data
  • Neurotransmitter Agents
  • Pesticides

Superlist Classification Code

  • Reportable Quantity (RQ) = 100 lb
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Ethyl paraoxon
  • Paraoxon

MeSH Heading

  • Paraoxon

Synonyms

  • 4-06-00-01327 (Beilstein Handbook Reference)
  • AI3-16087
  • BRN 1915526
  • CCRIS 7780
  • Chinorta
  • Chinorto
  • Diaethyl-p-nitrophenylphosphorsaeureester
  • Diaethyl-p-nitrophenylphosphorsaeureester [German]
  • Diethyl 4-nitrophenyl phosphate
  • Diethyl p-nitrophenyl phosphate
  • Diethyl paraoxon
  • Diethyl-p-nitrofenyl ester kyseliny fosforecne
  • Diethyl-p-nitrofenyl ester kyseliny fosforecne [Czech]
  • Diethylparaoxon
  • E 600
  • E 600 (pesticide)
  • E-600
  • EINECS 206-221-0
  • ENT 16,087
  • Ester 25
  • Ethyl p-nitrophenyl ethylphosphate
  • Ethyl paraoxon
  • Eticol
  • Fosfakol
  • HC 2072
  • HSDB 6044
  • Mintaco
  • Mintacol
  • Mintisal
  • Miotisal
  • Miotisal A
  • NSC 404110
  • O,O'Diaethyl-p-nitrophenylphosphat
  • O,O'Diaethyl-p-nitrophenylphosphat [German]
  • O,O-Diethyl O-p-nitrophenyl phosphate
  • O,O-Diethyl phosphoric acid O-p-nitrophenyl ester
  • O,O-Dietyl-O-p-nitrofenylfosfat
  • O,O-Dietyl-O-p-nitrofenylfosfat [Czech]
  • Oxyparathion
  • p-Nitrophenyl diethyl phosphate
  • p-Nitrophenyl diethylphosphate
  • Paraoxon
  • Paraoxone
  • Paroxan
  • Pestox 101
  • Phenol, p-nitro-, ester with diethyl phosphate
  • Phosphachole
  • Phosphacol
  • Phosphakol
  • Phosphonothioic acid, diethylparanitrophenyl ester
  • Phosphoric acid diethyl 4-nitrophenyl ester
  • Phosphoric acid, diethyl p-nitrophenyl ester
  • RCRA waste number P041
  • Soluglacit
  • Soluglaucit
  • TS 219
  • UNII-Q9CX8P80JW

Systematic Names

  • Diethyl 4-nitrophenyl phosphate
  • Paraoxon
  • Phosphoric acid, diethyl 4-nitrophenyl ester
  • Phosphoric acid, diethyl p-nitrophenyl ester

Superlist Names

  • Diethyl-p-nitrophenyl phosphate
  • Paraoxon
  • Phosphoric acid, diethyl 4-nitrophenyl ester
  • RCRA waste no. P041

Registry Numbers

CAS Registry Number

  • 311-45-5

FDA UNII

  • Q9CX8P80JW

System Generated Number

  • 0000311455

Structure Descriptors

InChI

1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

InChIKey

WYMSBXTXOHUIGT-UHFFFAOYSA-N

Smiles

P(=O)(Oc1ccc(cc1)[N+](=O)[O-])(OCC)OCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 subcutaneous 700ug/kg (0.7mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953.
chicken LD50 intramuscular 175ug/kg (0.175mg/kg)   Journal of Toxicology and Environmental Health. Vol. 23, Pg. 103, 1988.
chicken LD50 intraperitoneal 303ug/kg (0.303mg/kg)   Pesticide Biochemistry and Physiology. Vol. 26, Pg. 202, 1986.
chicken LD50 oral 2mg/kg (2mg/kg)   Biochemical Pharmacology. Vol. 16, Pg. 1183, 1967.
frog LD50 intraperitoneal 2587ug/kg (2.587mg/kg)   Pesticide Biochemistry and Physiology. Vol. 26, Pg. 202, 1986.
frog LD50 subcutaneous 60mg/kg (60mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953.
guinea pig LD50 subcutaneous 500ug/kg (0.5mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953.
man TDLo oral 14mg/kg (14mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Archiv fuer Toxikologie. Vol. 25, Pg. 329, 1969.
mouse LD50 intramuscular 710ug/kg (0.71mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 237, Pg. 211, 1959.
mouse LD50 intraperitoneal 330ug/kg (0.33mg/kg)   Farmakologiya i Toksikologiya Vol. 35, Pg. 494, 1972.
mouse LD50 intravenous 520ug/kg (0.52mg/kg)   Toxicology and Applied Pharmacology. Vol. 22, Pg. 684, 1972.
mouse LD50 oral 760ug/kg (0.76mg/kg)   HHS Publication Vol. FDA-80-1076, Pg. 212, 1980.
mouse LD50 subcutaneous 270ug/kg (0.27mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: TREMOR		 Journal of Pharmacy and Pharmacology. Vol. 34, Pg. 603, 1982.
mouse LD50 unreported 560ug/kg (0.56mg/kg)   Pharmaceutical Chemistry Journal Vol. 3, Pg. 508, 1969.
mouse LDLo parenteral 600ug/kg (0.6mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 388, 1973.
rabbit LD50 intraperitoneal 3310ug/kg (3.31mg/kg)   Archives Belges de Medecine Sociale, Hygiene, Medecine du Trevail et Medecine Legale. Vol. (Suppl), Pg. 226, 1984.
rabbit LD50 intravenous 300ug/kg (0.3mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953.
rabbit LD50 skin 5mg/kg (5mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. Vol. 57, Pg. 261, 1953.
rabbit LD50 subcutaneous 230ug/kg (0.23mg/kg)   Drugs in Japan Vol. 6, Pg. 113, 1982.
rabbit LD50 unreported 300ug/kg (0.3mg/kg)   American Journal of Ophthalmology. Vol. 53, Pg. 512, 1962.
rat LD50 intramuscular 446ug/kg (0.446mg/kg)   British Journal of Industrial Medicine. Vol. 22, Pg. 317, 1965.
rat LD50 intraperitoneal 716ug/kg (0.716mg/kg)   Pesticide Biochemistry and Physiology. Vol. 26, Pg. 202, 1986.
rat LD50 intravenous 240ug/kg (0.24mg/kg)   Canadian Journal of Biochemistry and Physiology. Vol. 34, Pg. 197, 1956.
rat LD50 oral 1800ug/kg (1.8mg/kg)   Biochemical Pharmacology. Vol. 16, Pg. 1183, 1967.
rat LD50 subcutaneous 426ug/kg (0.426mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1983, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 300 deg C   EXP
log P (octanol-water) 1.98 (none)   EXP
Water Solubility 3640 mg/L 20 EXP
Vapor Pressure 1.10E-06 mm Hg 25 EXP
Henry's Law Constant 1.09E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.91E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.