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Substance Name: Azacosterol [INN]
RN: 313-05-3
UNII: EPT876J73A
InChIKey: FMTFZYKYVZBISL-HUVRVWIJSA-N

Note

  • Diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase, which causes the accumulation of desmosterol.

Molecular Formula

  • C25-H44-N2-O

Molecular Weight

  • 388.6356
 

Classification Codes

  • Anticholesteremic Agents
  • Antimetabolites
  • Hypolipidemic Agents
  • Lipid Regulating Agents
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Names and Synonyms

Results Name

  • Azacosterol [INN]

Name of Substance

  • Azacosterol
  • Azacosterol [INN]

MeSH Heading

  • Azacosterol

Synonyms

  • 17-beta-((3-(Dimethylamino)propyl)methylamino)androst-5-en-3-beta-ol
  • 20,25-Diazacholesterol
  • Azacholesterol
  • Azacosterol
  • Azacosterolum
  • Azacosterolum [INN-Latin]
  • Diazasterol
  • IMD 760
  • UNII-EPT876J73A

Systematic Names

  • Androst-5-en-3-beta-ol, 17-beta-((3-(dimethylamino)propyl)methylamino)-
  • Androst-5-en-3-ol, 17-((3-(dimethylamino)propyl)methylamino)-, (3-beta,17-beta)- (9CI)
  • Androst-5-en-3-ol, 17-((3-(dimethylamino)propyl)methylamino)-, (3beta,17beta)-

Registry Numbers

CAS Registry Number

  • 313-05-3

FDA UNII

  • EPT876J73A

System Generated Number

  • 0000313053

Structure Descriptors

InChI

1S/C25H44N2O/c1-24-13-11-19(28)17-18(24)7-8-20-21-9-10-23(25(21,2)14-12-22(20)24)27(5)16-6-15-26(3)4/h7,19-23,28H,6,8-17H2,1-5H3/t19-,20-,21-,22-,23-,24-,25-/m0/s1

InChIKey

FMTFZYKYVZBISL-HUVRVWIJSA-N

Smiles

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2N(C)CCCN(C)C)CC=C4[C@@]3(CC[C@@H](C4)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 422mg/kg (422mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
mouse LD50 oral 90mg/kg (90mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 139, Pg. 100, 1972.