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Substance Name: Mikamycin IA
RN: 3131-03-1
UNII: V50XJ0NC3I
InChIKey: YGXCETJZBDTKRY-DZCVGBHJSA-N

Note

  • A specific streptogramin group B antibiotic produced by Streptomyces graminofaciens and other bacteria.

Molecular Formula

  • C45-H54-N8-O10

Molecular Weight

  • 866.9676
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
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Names and Synonyms

Results Name

  • Mikamycin IA

Name of Substance

  • Streptogramin B

MeSH Heading

  • Streptogramin B

Synonyms

  • 4-27-00-09718 (Beilstein Handbook Reference)
  • Antibiotic 899
  • Antibiotic PA 114 B1
  • Antibiotic PA 114B
  • BRN 0078387
  • Mikamycin B
  • Mikamycin IA
  • NSC 92554
  • Ostreogrycin B
  • PA 114B
  • Pristinamycin IA
  • Streptogramin B
  • UNII-V50XJ0NC3I
  • Vernamycin BA

Systematic Names

  • Vernamycin Balpha; Virginiamycin S1, 4-(4-(dimethylamino)-N-methyl-L-phenylalanine)- (9CI)
  • Virginiamycin S1, 4-(4(dimethylamino)-N-methyl-L-phenylalanine)-

Registry Numbers

CAS Registry Number

  • 3131-03-1

FDA UNII

  • V50XJ0NC3I

Other Registry Numbers

  • 11004-61-8
  • 11031-72-4
  • 27665-62-9
  • 29119-05-9
  • 4460-65-5
  • 992-77-8

System Generated Number

  • 0003131031

Structure Descriptors

InChI

1S/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)/t26-,31-,32+,33+,34+,36+,37+/m1/s1

InChIKey

YGXCETJZBDTKRY-DZCVGBHJSA-N

Smiles

CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]3CC(=O)CCN3C(=O)[C@H](Cc4ccc(cc4)N(C)C)N(C)C(=O)[C@@H]5CCCN5C1=O)c6ccccc6

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 350ug/kg (0.35mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 367, 1978.
mouse LD50 oral 200mg/kg (200mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 750, 1967.
mouse LD50 subcutaneous 200mg/kg (200mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 750, 1967.