Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Naftidrofuryl [INN:BAN]
RN: 31329-57-4
UNII: 42H8PQ0NMJ
InChIKey: KBAFPSLPKGSANY-UHFFFAOYSA-N

Note

  • A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.

Molecular Formula

  • C24-H33-N-O3

Molecular Weight

  • 383.5287
 

Classification Codes

  • Cardiovascular Agents
  • Neurotransmitter Agents
  • Serotonin Agents
  • Serotonin Antagonists
  • Vasodilator Agents
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Results Name

  • Naftidrofuryl [INN:BAN]

Name of Substance

  • Nafronyl
  • Naftidrofuryl [INN:BAN]

MeSH Heading

  • Nafronyl

Synonyms

  • 2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate
  • 3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl ester
  • alpha-Tetrahydrofurfuryl-1-naphthalenepropionic acid 2-(diethylamino)ethyl ester
  • BRN 1296059
  • EINECS 250-572-2
  • LS 84
  • N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate
  • Nafronyl
  • Naftidrofurilo
  • Naftidrofurilo [INN-Spanish]
  • Naftidrofuryl
  • Naftidrofurylum
  • Naftidrofurylum [INN-Latin]
  • Naphtidrofuryl
  • Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
  • Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester
  • Tridus
  • UNII-42H8PQ0NMJ

Systematic Names

  • 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester
  • 2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester
  • Naftidrofuryl

Registry Numbers

CAS Registry Number

  • 31329-57-4

FDA UNII

  • 42H8PQ0NMJ

Other Registry Number

  • 860-36-6

System Generated Number

  • 0031329574

Structure Descriptors

InChI

1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3

InChIKey

KBAFPSLPKGSANY-UHFFFAOYSA-N

Smiles

CCN(CC)CCOC(=O)C(Cc1cccc2c1cccc2)CC3CCCO3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 129mg/kg (129mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
mouse LD50 intravenous 23mg/kg (23mg/kg)   European Journal of Toxicology and Environmental Hygiene. Vol. 8, Pg. 188, 1975.
mouse LD50 oral 365mg/kg (365mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 10, Pg. 291, 1975.
mouse LD50 subcutaneous 272mg/kg (272mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
rat LD50 intraperitoneal 120mg/kg (120mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
rat LD50 oral 1890mg/kg (1890mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gendai no Rinsho. Vol. 5, Pg. 1, 1971.
rat LD50 subcutaneous 2500mg/kg (2500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Gendai no Rinsho. Vol. 5, Pg. 1, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.370 (none)   EST
Atmospheric OH Rate Constant 1.73E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.