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Substance Name: Grisorixin
RN: 31357-58-1
InChIKey: ZITSQIZMRMDQLE-RHQSYKMPSA-N

Note

  • Ionophorous antibiotic of nigericin group isolated from cultures of a strain of Streptomyces griseus.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C40-H68-O10

Molecular Weight

  • 708.967
 
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Names and Synonyms

Name of Substance

  • Grisorixin

Synonyms

  • 30-Deoxynigericin
  • Desoxynigericin
  • Grisorixin
  • Grisorixine

Systematic Name

  • Nigericin, 30-deoxy-

Registry Numbers

CAS Registry Number

  • 31357-58-1

System Generated Number

  • 0031357581

Structure Descriptors

InChI

1S/C40H68O10/c1-21-12-13-28(45-33(21)26(6)36(41)42)18-29-19-30(44-11)27(7)40(47-29)25(5)20-38(9,50-40)32-14-15-37(8,48-32)35-23(3)17-31(46-35)34-22(2)16-24(4)39(10,43)49-34/h21-35,43H,12-20H2,1-11H3,(H,41,42)/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+/m0/s1

InChIKey

ZITSQIZMRMDQLE-RHQSYKMPSA-N

Smiles

O1[C@]2(O[C@@H](C[C@H]([C@H]2C)OC)C[C@@H]2O[C@@H]([C@@H](C)CC2)[C@@H](C(O)=O)C)[C@@H](C[C@@]1([C@@H]1O[C@@]([C@@H]2O[C@@H]([C@H]3O[C@@]([C@H](C)C[C@@H]3C)(C)O)C[C@@H]2C)(C)CC1)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 9600ug/kg (9.6mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1502, 1980.
mouse LD50 subcutaneous 15mg/kg (15mg/kg)   Journal of Antibiotics. Vol. 28, Pg. 345, 1975.