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Substance Name: Evans blue [USP]
RN: 314-13-6
UNII: 45PG892GO1
InChIKey: ATNOAWAQFYGAOY-GPTZEZBUSA-J

Note

  • An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.

Molecular Formula

  • C34-H28-N6-O14-S4.4Na

Molecular Weight

  • 960.8156
 

Classification Codes

Classification Codes

  • Coloring Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms

Name of Substance

  • Evan's Blue
  • Evans blue
  • Evans blue [USP]

MeSH Heading

  • Evans blue

Synonyms

  • 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(4-amino-5-hydroxy)-, tetrasodium salt
  • 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(4-amino-5-hydroxy-, tetrasodium salt
  • 4,4'-Bis(1-amino-8-hydroxy-2,4-disulfo-7-naphthylazo)-3,3'-bitolyl, tetrasodium salt
  • 4,4'-Bis(1-amino-8-hydroxy-2,4-disulpho-7-naphthylazo)-3,3'-bitolyl, tetrasodium salt
  • 4,4'-Bis(7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo)-3,3'-bitolyl, tetrasodium salt
  • 4,4'-Bis(7-(1-amino-8-hydroxy-2,4-disulpho)naphthylazo)-3,3'-bitolyl, tetrasodium salt
  • Azovan Blue
  • Blekit evansa
  • Blekit evansa [Polish]
  • C.I. 23860
  • C.I. Direct Blue 53
  • C.I. direct blue 53 tetrasodium salt
  • CCRIS 167
  • Diamine Sky Blue FF
  • Diazobleu
  • Diazol Pure Blue BF
  • Direct Blue 53
  • Dye Evans Blue
  • EINECS 206-242-5
  • Evablin
  • Evans blue
  • Evans Blue Dye
  • Evans blue, sodium salt
  • Geigy Blue 536, med
  • Geigy-blau 536
  • Modr Evansova
  • Modr Evansova [Czech]
  • Modr Prima 53
  • Modr Prima 53 [Czech]
  • NSC 8680
  • T 1824
  • T-1824
  • T1824
  • UNII-45PG892GO1

Systematic Names

  • 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(2,1-diazenediyl))bis(4-amino-5-hydroxy-, sodium salt (1:4)
  • 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(4-amino-5-hydroxy-, tetrasodium salt
  • 1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis(4-amino-5-hydroxy-, tetrasodium salt
  • C.I. Direct Blue 53
  • C.I. Direct Blue 53, tetrasodium salt (8CI)
  • Tetrasodium 6,6'-(3,3'-dimethyl-(1,1'-biphenyl)-4,4'diyl)bis(azo)bis(4-amino-5-hydroxy-1,3-naphthalenedisulphonate)

Superlist Names

  • Direct Blue 53
  • Evans blue

Registry Numbers

CAS Registry Number

  • 314-13-6

FDA UNII

  • 45PG892GO1

Other Registry Number

  • 179472-53-8

System Generated Number

  • 0000314136

Molecular Formulas

Molecular Formula

  • C34-H28-N6-O14-S4.4Na

Molecular Formula Fragments

  • C34-H28-N6-O14-S4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C34H28N6O14S4.4Na/c1-15-11-17(3-7-21(15)37-39-23-9-5-19-25(55(43,44)45)13-27(57(49,50)51)31(35)29(19)33(23)41)18-4-8-22(16(2)12-18)38-40-24-10-6-20-26(56(46,47)48)14-28(58(52,53)54)32(36)30(20)34(24)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-37+,40-38+;;;;

InChIKey

ATNOAWAQFYGAOY-GPTZEZBUSA-J

Smiles

[Na+].[Na+].[Na+].[Na+].Cc1cc(ccc1N=Nc2ccc3c(cc(c(N)c3c2O)S(=O)(=O)[O-])S(=O)(=O)[O-])c4ccc(N=Nc5ccc6c(cc(c(N)c6c5O)S(=O)(=O)[O-])S(=O)(=O)[O-])c(C)c4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1mL/kg (1mL/kg) LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives of Surgery Vol. 48, Pg. 17, 1944.
dog LDLo intravenous 3mL/kg (3mL/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Archives of Surgery Vol. 48, Pg. 17, 1944.
mouse LD50 intraperitoneal 340mg/kg (340mg/kg)   Biochemical and Biophysical Research Communications. Vol. 136, Pg. 64, 1986.
rabbit LDLo intravenous 1mL/kg (1mL/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Archives of Surgery Vol. 48, Pg. 17, 1944.
rat LDLo intravenous 5mL/kg (5mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: OTHER CHANGES
Archives of Surgery Vol. 48, Pg. 17, 1944.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.710 (none)   EST
Atmospheric OH Rate Constant 4.39E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.