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Substance Name: Etamiphyllin [INN]
RN: 314-35-2
UNII: 221A91BQ2S
InChIKey: AWKLBIOQCIORSB-UHFFFAOYSA-N

Classification Codes

  • Anti-Asthmatic Agents
  • Autonomic Agents
  • Bronchodilator Agents
  • Human Data
  • Peripheral Nervous System Agents
  • Respiratory System Agents

Molecular Formula

  • C13-H21-N5-O2

Molecular Weight

  • 279.3419
 
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Names and Synonyms

Name of Substance

  • Etamiphyllin
  • Etamiphyllin [INN]

Synonyms

  • 1,3-Dimethyl-7-(2-(diethylamino)ethyl)xanthine
  • 4-26-00-02409 (Beilstein Handbook Reference)
  • 7-(2-(Diethylamino)ethyl)-1,3-dimethylxanthine
  • 7-(2-(Diethylamino)ethyl)theophylline
  • 7-(Diethylaminoethyl)theophylline
  • BRN 0291098
  • Camphophyline
  • Corafil
  • Diaethylaminoaethyl-theophyllin
  • Diaethylaminoaethyl-theophyllin [German]
  • Diethylaminoethyl theophylline
  • Diethylaminoethyltheophylline
  • EINECS 206-244-6
  • Etamifilina
  • Etamifilina [INN-Spanish]
  • Etamifillina
  • Etamifillina [DCIT]
  • Etaminophylline
  • Etamiphyllin
  • Etamiphylline
  • Etamiphylline [INN-French]
  • Etamiphyllinum
  • Etamiphyllinum [INN-Latin]
  • Milliphylline
  • Millophylline
  • NSC 38348
  • Parephyllin
  • Queryl
  • R-3588
  • Solufilina
  • Soluphyline
  • UNII-221A91BQ2S

Systematic Names

  • 1H-Purine-2,6-dione, 7-(2-(diethylamino)ethyl)-3,7-dihydro-1,3-dimethyl- (9CI)
  • 7-(2-Diethylaminoethyl)theophylline
  • 7-(beta-Diethylaminoethyl)theophylline
  • Etamiphyllin
  • Theophylline, 7-(2-diethylamino)ethyl-

Registry Numbers

CAS Registry Number

  • 314-35-2

FDA UNII

  • 221A91BQ2S

Related Registry Number

  • 17140-68-0 (mono-hydrochloride)

System Generated Number

  • 0000314352

Structure Descriptors

InChI

1S/C13H21N5O2/c1-5-17(6-2)7-8-18-9-14-11-10(18)12(19)16(4)13(20)15(11)3/h9H,5-8H2,1-4H3

InChIKey

AWKLBIOQCIORSB-UHFFFAOYSA-N

Smiles

CCN(CC)CCn1cnc2c1c(=O)n(c(=O)n2C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 254mg/kg (254mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 343, 1956.
mouse LD50 oral 1237mg/kg (1237mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 343, 1956.
mouse LD50 subcutaneous 182mg/kg (182mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 649, 1954.
women TDLo oral 240mg/kg (240mg/kg) CARDIAC: CHANGE IN RATE

SENSE ORGANS AND SPECIAL SENSES: CHANGE IN OLFACTORY NERVE: OLFACTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Human & Experimental Toxicology. Vol. 9, Pg. 201, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 75 deg C   EXP
log P (octanol-water) 0.840 (none)   EST
Atmospheric OH Rate Constant 1.15E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.