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Substance Name: Nocodazole [USAN:INN]
RN: 31430-18-9
UNII: SH1WY3R615
InChIKey: KYRVNWMVYQXFEU-UHFFFAOYSA-N

Note

  • Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.

Molecular Formula

  • C14-H11-N3-O3-S

Molecular Weight

  • 301.3249
 

Classification Codes

  • Antimitotic Agents
  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Mitosis Modulators
  • Mutation Data
  • Reproductive Effect
  • Tubulin Modulators
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Names and Synonyms

Name of Substance

  • Nocodazole
  • Nocodazole [USAN:INN]

MeSH Heading

  • Nocodazole

Synonyms

  • 2-Benzimidazolecarbamic acid, 5-(2-thienylcarbonyl)-, methyl ester
  • Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester
  • Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazole-2-yl)-, methyl ester
  • EINECS 250-626-5
  • Methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate
  • Methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)carbamate
  • Methyl 5-(2-thenoyl)-2-benzimidazolecarbamate
  • N-(5-(2-Thenoyl)-2-benzimidazolyl)carbamic acid methyl ester
  • Nocidazole
  • Nocodazol
  • Nocodazol [INN-Spanish]
  • Nocodazole
  • Nocodazolum
  • Nocodazolum [INN-Latin]
  • NSC 238 159
  • NSC 238159
  • Oncodazole
  • R 17,934
  • R 17934
  • UNII-SH1WY3R615

Systematic Names

  • 2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester
  • Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester
  • Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester (9CI)
  • Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazole-2-yl)-, methyl ester
  • Nocodazole

Registry Numbers

CAS Registry Number

  • 31430-18-9

FDA UNII

  • SH1WY3R615

System Generated Number

  • 0031430189

Structure Descriptors

InChI

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChIKey

KYRVNWMVYQXFEU-UHFFFAOYSA-N

Smiles

c12c([nH]c(n2)NC(OC)=O)ccc(c1)C(c1cccs1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 39530ug/kg (39.53mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,