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Substance Name: Mebendazole [USAN:USP:INN:BAN:JAN]
RN: 31431-39-7
UNII: 81G6I5V05I
InChIKey: OPXLLQIJSORQAM-UHFFFAOYSA-N
Note
- A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
Molecular Formula
- C16-H13-N3-O3
Molecular Weight
- 295.2967
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anthelmintic
- Anthelmintics
- Anti-Infective Agents
- Antimitotic Agents
- Antinematodal Agents
- Antiparasitic Agents
- Drug / Therapeutic Agent
- Mitosis Modulators
- Mutation Data
- Reproductive Effect
- Tubulin Modulators
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Names and Synonyms
Name of Substance
- Mebendazole
- Mebendazole [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Mebendazole
Synonyms
- (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester
- 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester
- 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester
- Bantenol
- Besantin
- Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester
- CCRIS 4479
- EINECS 250-635-4
- Emverm
- HSDB 3232
- Lomper
- MBDZ
- Mebendazol
- Mebendazol [INN-Spanish]
- Mebendazole
- Mebendazolum
- Mebendazolum [INN-Latin]
- Mebenoazole
- Mebenvet
- Mebutar
- Methyl 5-benzoyl benzimidazole-2-carbamate
- Methyl 5-benzoyl-2-benzimidazolecarbamate
- Methyl 5-benzoyl-2-benzimidazolylcarbamate
- Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate
- N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle
- N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle [French]
- N-2 (5-Benzoyl-benzimidazole) carbamate de methyle
- N-2 (5-Benzoyl-benzimidazole) carbamate de methyle [French]
- Noverme
- NSC 184849
- Ovitelmin
- Pantelmin
- R 17,635
- R 17635
- Sufil
- Telmin
- UNII-81G6I5V05I
- Vermicidin
- Vermirax
- Vermox
- Verpanyl
- Versid
Systematic Names
- 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester (8CI)
- Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester
- Carbamic acid, N-(5-benzoylbenzimidazol-2-yl)-, methyl ester
- Mebendazole
Superlist Name
- Mebendazole
Registry Numbers
CAS Registry Number
- 31431-39-7
FDA UNII
- 81G6I5V05I
System Generated Number
- 0031431397
Structure Descriptors
InChI
InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)InChIKey
OPXLLQIJSORQAM-UHFFFAOYSA-NSmiles
COC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | > 640mg/kg (640mg/kg) | Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973. | |
chicken | LD50 | unreported | > 40mg/kg (40mg/kg) | United States Patent Document. Vol. #3657267, | |
dog | LD | intramuscular | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. -, Pg. 1207, 1990. | |
dog | LD50 | oral | 1280mg/kg (1280mg/kg) | Drugs in Japan Vol. -, Pg. 1207, 1990. | |
domestic animals - goat/sheep | LD50 | oral | > 80mg/kg (80mg/kg) | United States Patent Document. Vol. #3657267, | |
guinea pig | LD50 | oral | > 1280mg/kg (1280mg/kg) | Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973. | |
mouse | LD50 | intraperitoneal | 712mg/kg (712mg/kg) | Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. Vol. 48(4), Pg. 29, 1979. | |
mouse | LD50 | oral | 620mg/kg (620mg/kg) | Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. Vol. 47(6), Pg. 48, 1978. | |
rabbit | LD50 | oral | > 640mg/kg (640mg/kg) | Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973. | |
rat | LD50 | intramuscular | 350mg/kg (350mg/kg) | Drugs in Japan Vol. -, Pg. 1207, 1990. | |
rat | LD50 | oral | 714mg/kg (714mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 288.5 | deg C | EXP | |
log P (octanol-water) | 2.83 | (none) | EXP | |
Water Solubility | 71.3 | mg/L | 25 | EXP |
Vapor Pressure | 5.33E-11 | mm Hg | 25 | EST |
Henry's Law Constant | 5.36E-16 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.36E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.