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Substance Name: Opipramol [INN:BAN]
RN: 315-72-0
UNII: D23ZXO613C
InChIKey: YNZFUWZUGRBMHL-UHFFFAOYSA-N

Note

  • A tricyclic antidepressant with actions similar to AMITRIPTYLINE.

Molecular Formula

  • C23-H29-N3-O

Molecular Weight

  • 363.5021
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs
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Names and Synonyms

Results Name

  • Opipramol [INN:BAN]

Name of Substance

  • Opipramol
  • Opipramol [INN:BAN]

MeSH Heading

  • Opipramol

Synonyms

  • 4-(3-(5H-Dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanol
  • 5-23-01-00475 (Beilstein Handbook Reference)
  • 5H-Dibenz(b,f)azepine, 5-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)-
  • BRN 0627076
  • EINECS 206-254-0
  • N-(3-(4-(2-Hydroxyethyl)piperazino)propyl)iminostilbene
  • Nisidana
  • NSC 169867
  • Opipramol
  • Opipramol G
  • Opipramolum
  • Opipramolum [INN-Latin]
  • UNII-D23ZXO613C

Systematic Names

  • 1-Piperazineethanol, 4-(3-(5H-dibenz(b,f)azepin-5-yl)propyl)-
  • Opipramol

Registry Numbers

CAS Registry Number

  • 315-72-0

FDA UNII

  • D23ZXO613C

Related Registry Number

  • 909-39-7 (hydrochloride)

System Generated Number

  • 0000315720

Structure Descriptors

InChI

1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2

InChIKey

YNZFUWZUGRBMHL-UHFFFAOYSA-N

Smiles

N1(c2c(C=Cc3c1cccc3)cccc2)CCCN1CCN(CC1)CCO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 120mg/kg (120mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
mouse LD50 intravenous 45mg/kg (45mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
mouse LD50 oral 400mg/kg (400mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 181, Pg. 68, 1969.
mouse LD50 subcutaneous 315mg/kg (315mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rabbit LD50 intravenous 11mg/kg (11mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rat LD50 intraperitoneal 95mg/kg (95mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rat LD50 intravenous 32mg/kg (32mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rat LD50 oral 1110mg/kg (1110mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 subcutaneous 497mg/kg (497mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 100.5 deg C   EXP
log P (octanol-water) 3.410 (none)   EST
Atmospheric OH Rate Constant 4.69E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.